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首页> 外文期刊>Sao Paulo Medical Journal >Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis
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Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis

机译：盆腔子宫内膜异位症患者血清与腹膜液CA-125水平呈正相关

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CONTEXT AND OBJECTIVE: One of the diagnostic markers of endometriosis is CA-125, and elevated levels of this are caused by high concentrations in the ectopic endometrium. The objective of this study was to correlate CA-125 levels in serum and peritoneal fluid from women with and without pelvic endometriosis. DESIGN AND SETTING: This was a prospective, cross-sectional, controlled study of consecutive pa-tients undergoing laparoscopy for infertility, pelvic pain or tubal ligation, during early follicular phase, at the university hospital of Faculdade de Medicina de Ribeir?o Preto. METHODS: Fifty-two patients were divided into two groups: endometriosis group, consisting of 35 patients with biopsy-confirmed pelvic endometriosis, and control group, consisting of 17 patients without endometriosis. CA-125 levels in serum samples and peritoneal fluid were determined by chemiluminescence. RESULTS: CA-125 levels in serum and peritoneal fluid were higher in patients with advanced pelvic endometriosis (means of 39.1 ± 45.8 U/ml versus 10.5 ± 5.9 U/ml in serum, p < 0.005; 1,469.4 ± 1,350.4 U/ml versus 888.7 ± 784.3 U/ml in peritoneal fluid, p < 0.05), and showed a positive correlation between each other (correlation coefficient (r) = 0.4880). Women with more advanced degrees of endometriosis showed higher CA-125 levels in both serum and peritoneal fluid (p = 0.0001). CONCLUSION: There is a positive correlation between serum and peritoneal fluid values of CA-125 in women with and without endometriosis, and their levels are higher in peritoneal fluid. Advanced endometriosis is related to higher levels in both serum and peritoneal fluid.
机译：背景与目的：子宫内膜异位症的诊断标志之一是CA-125，其水平升高是由于异位子宫内膜的高浓度引起的。这项研究的目的是关联有和没有骨盆子宫内膜异位症的女性血清和腹膜液中CA-125的水平。设计与地点：这是一项对前连续性患者进行的前瞻性，对照研究，该研究在卵泡早期，在Faculdade de Medicina de Ribeir？o Preto的大学医院接受腹腔镜检查以检查不孕，骨盆疼痛或输卵管结扎的患者。方法：52例患者分为两组：子宫内膜异位组35例，经活检证实为盆腔子宫内膜异位，对照组17例，无子宫内膜异位。通过化学发光测定血清样品和腹膜液中的CA-125水平。结果：晚期骨盆子宫内膜异位症患者的血清和腹膜液中CA-125水平较高（平均值为39.1±45.8 U / ml对血清的10.5±5.9 U / ml，p <0.005; 1,469.4±1,350.4 U / ml对888.7腹膜液中的浓度为±784.3 U / ml，p <0.05），并且彼此之间呈正相关（相关系数（r）= 0.4880）。子宫内膜异位症程度更高的女性在血清和腹膜液中均显示较高的CA-125水平（p = 0.0001）。结论：子宫内膜异位症和非子宫内膜异位症的女性血清和腹膜液中CA-125的含量呈正相关，而腹膜液中CA-125的水平较高。晚期子宫内膜异位症与血清和腹膜液水平升高有关。

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