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首页> 外文期刊>Sao Paulo Medical Journal >Incidence of postoperative dyspepsia is not associated with prophylactic use of drugs
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Incidence of postoperative dyspepsia is not associated with prophylactic use of drugs

机译：术后消化不良的发生与预防性使用药物无关

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CONTEXT AND OBJECTIVE: Preoperative fasting guidelines do not recommend H2 receptor antagonists or proton pump inhibitors. This study investigated prophylactic use of gastric protection and the incidence of dyspeptic symptoms in the immediate postoperative period.DESIGN AND SETTING: Non-randomized observational investigation in a post-anesthesia care unit.METHODS: American Society of Anesthesiologists risk classification ASAP1 and ASAP2 patients over 18 years of age were evaluated to identify dyspeptic symptoms during post-anesthesia care for up to 48 hours, after receiving or not receiving prophylactic gastric protection during anesthesia. History of dyspeptic symptoms and previous use of such medications were exclusion criteria. The odds ratio for incidence of dyspeptic symptoms with use of these medications was obtained.RESULTS: This investigation studied 188 patients: 71% women; 50.5% ASAP1 patients. Most patients received general anesthesia (68%). Gastric protection was widely used (n = 164; 87.2%), comprising omeprazole (n = 126; 76.8%) or ranitidine (n = 38; 23.2%). Only a few patients did not receive any prophylaxis (n = 24; 12.8%). During the observation, 24 patients (12.8%) reported some dyspeptic symptoms but without any relationship with prophylaxis (relative risk, RR = 0.56; 95% confidence interval, CI: 0.23-1.35; P = 0.17; number needed to treat, NNT = 11). Omeprazole, compared with ranitidine, did not reduce the chance of having symptoms (RR = 0.65; 95% CI: 0.27-1.60; P = 0.26; NNT = 19).CONCLUSION: This study suggests that prophylactic use of proton pump inhibitors or H2 receptor antagonists was routine for asymptomatic patients and was not associated with postoperative protection against dyspeptic symptoms.
机译：背景与目的：术前禁食指南不建议使用H2受体拮抗剂或质子泵抑制剂。本研究调查了术后即刻预防性使用胃保护和消化不良症状的发生率。设计和设置：麻醉后护理部门的非随机观察性研究。方法：美国麻醉医师学会风险分级ASAP1和ASAP2患者超过在麻醉期间接受或未接受预防性胃保护后，对18岁以下患者进行评估，以识别麻醉后长达48小时的消化不良症状。消化不良症状的病史和此类药物的先前使用是排除标准。结果：本研究调查了188例患者，其中71％为女性，其中80％为消化不良症状。 50.5％的ASAP1患者。大多数患者接受全身麻醉（68％）。胃保护被广泛使用（n = 164; 87.2％），包括奥美拉唑（n = 126; 76.8％）或雷尼替丁（n = 38; 23.2％）。只有少数患者未接受任何预防（n = 24; 12.8％）。在观察期间，有24位患者（12.8％）报告有消化不良症状，但与预防没有任何关系（相对风险，RR = 0.56; 95％置信区间，CI：0.23-1.35; P = 0.17;需要治疗的数量，NNT = 11）。奥美拉唑与雷尼替丁相比，并没有减少出现症状的机会（RR = 0.65; 95％CI：0.27-1.60; P = 0.26; NNT = 19）。结论：这项研究表明，预防性使用质子泵抑制剂或H2对于无症状患者，受体拮抗剂是常规治疗，并且没有针对消化不良症状的术后保护措施。

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