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首页> 外文期刊>Sao Paulo Medical Journal >Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods
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Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods

机译：慢性肾脏疾病-进展和心血管风险的决定因素。 PROGREDIR队列研究：设计和方法

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CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters. DESIGN AND SETTING: Prospective cohort study; S?￡o Paulo, Brazil. METHODS: Recruitment took place in Hospital das Cl?-nicas, S?￡o Paulo, from March 2012 to December 2013. Data relating to medical history, food-frequency questionnaire, anthropometry, laboratory work-up, calcium score, echocardiography, carotid intimal-medial thickness, pulse-wave velocity, retinography and heart rate variability were collected. A biobank including serum, plasma, post-oral glucose tolerance test serum and plasma, urine (morning and 24-hour urine) and DNA was established. RESULTS: 454 participants (60% men and 50% diabetics) of mean age 68 years were enrolled. Their mean estimated glomerular filtration rate-CKD Epidemiology Collaboration was 38 ml/min/1.73 m 2 . Follow-up is ongoing and the main outcomes are the start of RRT, cardiovascular events and death. CONCLUSIONS: The PROGREDIR cohort is a promising prospective study that will allow better understanding of CKD determinants and validation of candidate biomarkers for the risks of CKD progression and mortality.
机译：背景与目的：慢性肾脏病（CKD）已成为重要的公共卫生问题。肾脏替代疗法（RRT）的社会经济负担非常高，与CKD相关的心血管死亡率和发病率也很高。预防和治疗措施的影响很小，需要更多的研究。很少有关于CKD人群的队列研究。我们的目标是建立一个队列，其中包括更高级的CKD形式（第3阶段和第4阶段）。数据收集的重点是肾脏和心血管参数。设计与地点：前瞻性队列研究;巴西圣保罗。方法：于2012年3月至2013年12月在圣保罗圣克鲁斯尼加斯医院进行了招募。有关病史，食物频率问卷，人体测量学，实验室检查，钙分，超声心动图，颈动脉的数据收集内膜中层厚度，脉搏波速度，视网膜成像和心率变异性。建立了包括血清，血浆，口服葡萄糖耐量试验血清和血浆，尿液（早晨和24小时尿液）和DNA的生物库。结果：454名参与者（60％的男性和50％的糖尿病患者）的平均年龄为68岁。他们的平均估计肾小球滤过率-CKD流行病学协作为38 ml / min / 1.73 m 2。随访正在进行中，主要结局是RRT，心血管事件和死亡的开始。结论：PROGREDIR队列是一项有前途的前瞻性研究，将有助于更好地了解CKD决定因素，并验证CKD进展和死亡风险的候选生物标志物。

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