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首页> 外文期刊>Sao Paulo Medical Journal >What do Cochrane systematic reviews say about interventions for treating psoriasis?
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What do Cochrane systematic reviews say about interventions for treating psoriasis?

机译：Cochrane系统评价对牛皮癣的干预措施有何评论？

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CONTEXT AND OBJECTIVE: Psoriasis is a common chronic inflammatory skin disease characterized by abnormal and increased growth of the cells that produce keratin and abnormal functioning of the immune system. We aimed to summarize the evidence available regarding interventions for patients with psoriasis. DESIGN AND SETTING: Review of systematic reviews, developed in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de S?o Paulo. METHODS: A systematic search was conducted to identify Cochrane systematic reviews that fulfilled the eligibility criteria. Two authors screened titles and abstracts that had been retrieved through the search strategy. The results from all the Cochrane systematic reviews that were included were summarized and presented in a narrative synthesis. RESULTS: We included six Cochrane systematic reviews assessing interventions for treating psoriasis. The findings from high-quality evidence were that (a) etanercept reduced the psoriasis severity index, compared with placebo and (b) steroids plus vitamin D, compared with vitamin D alone, improved the skin clearance rate, as assessed by investigators, but was associated with a higher proportion of participants who dropped out due to adverse events. For all other comparisons, the quality of the evidence ranged from moderate to very low. CONCLUSION: This review included six Cochrane systematic reviews that provided evidence ranging in quality from unknown to high, regarding management of psoriasis. Further randomized controlled trials are imperative to reduce the uncertainties relating to several treatments that are already used in clinical practice.
机译：背景与目的：银屑病是一种常见的慢性炎症性皮肤病，其特征是产生角蛋白的细胞生长异常和增长，免疫系统功能异常。我们旨在总结有关牛皮癣患者干预措施的可用证据。设计与环境：系统评价的回顾，由循证医学学科，Escola Paulista de Medicina，圣保罗大学组成。方法：进行系统搜索以鉴定符合资格标准的Cochrane系统评价。两位作者筛选了通过搜索策略检索到的标题和摘要。来自所有Cochrane系统评价的结果均已汇总，并以叙述性综述的形式呈现。结果：我们纳入了六项Cochrane系统评价，评估了治疗牛皮癣的干预措施。高质量证据表明，（a）依那西普与安慰剂相比可降低牛皮癣严重程度指数，（b）类固醇加维生素D（与单独使用维生素D相比）可改善皮肤清除率（经研究者评估），但与因不良事件而退学的参与者比例较高有关。对于所有其他比较，证据的质量从中等到非常低不等。结论：本评价包括六项Cochrane系统评价，这些评价提供了有关牛皮癣治疗的证据，质量从未知到高度不等。必须进行进一步的随机对照试验，以减少与临床实践中已经使用的几种治疗方法有关的不确定性。

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