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首页> 外文期刊>Sao Paulo Medical Journal >Effects of hypertension on maternal adaptations to pregnancy: experimental study on spontaneously hypertensive rats
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Effects of hypertension on maternal adaptations to pregnancy: experimental study on spontaneously hypertensive rats

机译：高血压对母体适应妊娠的影响：自发性高血压大鼠的实验研究

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CONTEXT: Animal models for essential hypertension have been used for understanding the human pathological conditions observed in pregnant hypertensive women. OBJECTIVE: To study the possible effects of pregnancy on hypertension and of hypertension on pregnancy in spontaneously hypertensive rats (SHR), and in their normotensive Wistar-Kyoto (WKY) counterparts. TYPE OF STUDY: Comparative study using laboratory animals. SETTING: Animal Research Laboratory of Clinical Medicine at the Medical School of Botucatu, S?o Paulo State University, Brazil. SAMPLE: Ten to twelve-week-old virgin female normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). The animals were separated into four groups: 15 pregnant spontaneously hypertensive rats (SHR-P), 10 non-pregnant spontaneously hypertensive rats (SHR-NP), 15 pregnant normotensive rats (WKY-P), and 10 non-pregnant normotensive rats (WKY-NP). MAIN MEASUREMENTS: The blood pressure was evaluated by the tail cuff method, in rats either with or without prior training for the handling necessary for tail cuff measurements. The maternal volemia expansion was indirectly evaluated by weight gain, and by systemic parameters as hematocrit, hemoglobin, total protein, albumin and sodium retention. The perinatal outcome of pregnancy was evaluated by analysis of resorptions, litter size, rate of low weight and number of stillbirths. RESULTS: The late fall in blood pressure in the pregnant SHR strain and in the normotensive WKY strain can only be detected in rats previously trained to accept the handling necessary for the tail cuff measurement. During pregnancy the body weight gain was significantly higher in WKY than in SHR rats. Systemic parameters were significantly lower in pregnant WKY rats than in non-pregnant WKY rats, while no differences were observed between pregnant and non-pregnant SHR groups. In pregnant WKY rats the sodium retention was higher from the 13th day onwards, while in SHR rats this occurred only on the 21st day. The characteristics of reproductive function such as number and weight of fetus, perinatal mortality and the resorption rate were significantly affected in the SHR strain. CONCLUSION: The SHR strain may be considered as a model for chronic hypovolemic maternal hypertension, with the fetal growth retardation being determined by this hypovolemic state.
机译：背景：原发性高血压的动物模型已用于了解在孕妇高血压妇女中观察到的人体病理状况。目的：研究妊娠对自发性高血压大鼠（SHR）和血压正常的Wistar-Kyoto（WKY）对高血压的影响以及高血压对妊娠的影响。研究类型：使用实验动物进行的比较研究。地点：巴西圣保罗州立大学Botucatu医学院临床医学动物研究实验室。示例：十至十二周大的处女雌性正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）。将动物分为四组：15只妊娠自发性高血压大鼠（SHR-P），10只非妊娠自发性高血压大鼠（SHR-NP），15只妊娠正常血压大鼠（WKY-P）和10只非妊娠性正常血压大鼠（SHR-P） WKY-NP）。主要测量：在接受或未接受事先训练以进行尾袖测量所需的处理的大鼠中，通过尾袖方法评估血压。通过体重增加和血细胞比容，血红蛋白，总蛋白，白蛋白和钠retention留等全身性参数间接评估母体血容量的增加。通过分析吸收率，产仔数，低体重发生率和死产数量来评估围产期妊娠结局。结果：仅在先前接受训练以接受尾巴测量所需的处理方法的大鼠中，才能检测到孕妇SHR品系和血压正常的WKY品系中的晚期血压下降。在怀孕期间，WKY的体重增加显着高于SHR大鼠。怀孕的WKY大鼠的系统参数显着低于未怀孕的WKY大鼠，而怀孕和未怀孕的SHR组之间没有发现差异。在怀孕的WKY大鼠中，从第13天开始钠保留更高，而在SHR大鼠中，钠保留仅在第21天出现。生殖功能的特征，例如胎儿的数量和体重，围产期死亡率和再吸收率，在SHR菌株中受到显着影响。结论：SHR菌株可被视为慢性低血容量母体高血压的模型，胎儿生长迟缓是由这种低血容量状态决定的。

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