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首页> 外文期刊>Sao Paulo Medical Journal >Effects of ondansetron on respiratory pattern and sensation of experimentally induced dyspnea
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Effects of ondansetron on respiratory pattern and sensation of experimentally induced dyspnea

机译：恩丹西酮对实验性呼吸困难的呼吸模式和感觉的影响

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CONTEXT: Dyspnea remains a therapeutic challenge, especially in chronic respiratory conditions. Recent studies have shown that the induction of unpleasant dyspnea sensations activates areas in the insular cortex. OBJECTIVE: This study was designed to investigate the potential effects of ondansetron, a potent anti-serotonin agent, on induced dyspnea sensation. TYPE OF STUDY: A randomized double blind study. SETTING: Pulmonary Function Laboratory of Hospital das Clínicas de Ribeir?o Preto. PARTICIPANTS: Ten healthy male volunteers (mean age ± standard error = 23.1 ± 0.41 years) without respiratory diseases and showing normal spirometric tests. INTERVENTIONS: Uncomfortable breathing was induced in the volunteers on two different days, via the use of inspiratory resistors (loads of 0, 7, 14 and 21 cm H2O/l/sec) and breathholding, two hours after taking 8 mg of ondansetron (Ond) or placebo (Plac). MAIN MEASUREMENTS: Respiratory discomfort during breathing under loading was evaluated on a 100-mm visual analog scale. The maximum length of time of voluntary apnea was measured in seconds. RESULTS: The mean maximum voluntary apnea time did not differ between the ondansetron and placebo days (Plac = 96 ± 6.6 sec vs. Ond = 100 ± 7.9 sec). Ondansetron did not influence the dyspnea sensation induced by different inspiratory loads (0 cm H2O/l/sec: Ond = 1.4 mm ± 0.44 vs. Plac = 2.1 ± 0.85 mm; 7 cm H2O/l/sec: Ond = 16.6 ± 2.74 mm vs. Plac = 13.7 ± 2.06 mm; 14 cm H2O/l/sec; Ond = 30.5 ± 4.50 mm vs. Plac = 27.1 ± 3.44 mm; 21 cm H2O/l/sec: Ond = 50.3 ± 6.72 mm vs. Plac = 49.4 ± 6.72 mm). Ondansetron led to significant decreases in tidal volume under basal conditions and when breathing under the highest inspiratory loading (0 cm H2O/l/sec: Ond = 0.83 ± 0.26 l vs. Plac = 1.0 ± 0.28 l; 21 cm H2O/l/sec: Ond = 0.86 ± 0.23 l vs. Plac = 1.1 ± 0.22 l) CONCLUSION: The present results suggest that 5-HT3 receptors do not play an important role in the mediation of dyspnea sensations.
机译：背景：呼吸困难仍然是一种治疗挑战，尤其是在慢性呼吸道疾病中。最近的研究表明，令人不快的呼吸困难感的诱导激活了岛状皮层中的区域。目的：本研究旨在研究强效抗5-羟色胺剂恩丹西酮对诱发的呼吸困难感的潜在影响。研究类型：随机双盲研究。地点：里贝里奥普雷图医院的肺功能实验室。参与者：10名健康男性志愿者（平均年龄±标准差= 23.1±0.41岁），无呼吸系统疾病，肺活量测试正常。干预措施：服用8毫克的恩丹西酮（Ond）后两小时，通过使用吸气阻力器（负荷分别为0、7、14和21 cm H2O / l / sec）并屏住呼吸，两天后志愿者体内呼吸不舒服。 ）或安慰剂（Plac）。主要测量：负荷下呼吸期间的呼吸不适以100毫米视觉模拟量表进行评估。自愿呼吸暂停的最大时间长度以秒为单位。结果：在恩丹西酮和安慰剂天之间，平均最大自主呼吸暂停时间无差异（Plac = 96±6.6秒，而Ond = 100±7.9秒）。恩丹西酮不会影响不同吸气负荷引起的呼吸困难感（0 cm H2O / l / sec：Ond = 1.4 mm±0.44 vs. Plac = 2.1±0.85 mm; 7 cm H2O / l / sec：Ond = 16.6±2.74 mm vs.Plac = 13.7±2.06 mm; 14 cm H2O / l / sec; Ond = 30.5±4.50 mm vs.Plac = 27.1±3.44 mm; 21 cm H2O / l / sec：Ond = 50.3±6.72 mm vs.Plac = 49.4±6.72毫米）。在基础条件下以及在最大吸气负荷下呼吸时（0 cm H2O / l / sec：Ond = 0.83±0.26 l vs.Plac = 1.0±0.28 l; 21 cm H2O / l / sec），Ondansetron导致潮气量显着减少：Ond = 0.86±0.23 l vs. Plac = 1.1±0.22 l）结论：目前的结果表明5-HT 3受体在呼吸困难感的介导中不发挥重要作用。

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