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首页> 外文期刊>Schizophrenia research and treatment >Polyphenols from Berries ofAronia melanocarpaReduce the Plasma Lipid Peroxidation Induced by Ziprasidone
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Polyphenols from Berries ofAronia melanocarpaReduce the Plasma Lipid Peroxidation Induced by Ziprasidone

机译：紫罗兰（Aronia melanocarpa）浆果中的多酚减少齐普西酮诱导的血浆脂质过氧化

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Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries ofAronia melanocarpa(Aronox) on the plasma lipid peroxidation induced by ziprasidonein vitro.Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml).Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation:P=7.0× 10−4,P=1.6× 10−3, andP=2.7× 10−3, resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased:P=6.5× 10−8,P=7.0× 10−6, andP=3.0× 10−5, respectively.Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.
机译：背景。精神分裂症的氧化应激可能部分由抗精神病药治疗引起。本研究的目的是建立源自野Ar（Aronia melanocarpa）（Aronox）浆果的多酚化合物对齐拉西酮体外诱导的血浆脂质过氧化的影响。通过硫代巴比妥酸反应性物质（TBARS）的水平测量脂质过氧化。将健康受试者的血浆样品分别与ziprasidone（40μng/ ml; 139μng/ ml;和250μng/ ml）和Aronox（5μug/ ml;50μug/ ml）孵育。我们观察到血浆与ziprasidone（40μng/ ml;139μng/ ml;和250μng/ ml）孵育后，TBARS水平有统计学上的显着增加（孵育24小时后：P = 7.0×10−4，P = 1.6× 10−3和P = 2.7×10−3），齐拉西酮引起的Aronox脂质过氧化明显降低。在50μug/ ml Aronox存在下，将血浆与齐拉西酮（40μng/ ml;139μng/ ml;和250μng/ ml）孵育24小时后，TBARS的水​​平显着降低：P = 6.5×10−分别为8，P = 7.0×10-6和P = 3.0×10-5。 Aronox导致齐拉西酮诱导的脂质过氧化作用明显降低。

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