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首页> 外文期刊>Sao Paulo Medical Journal >Labor analgesia with ropivacaine added to clonidine: a randomized clinical trial
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Labor analgesia with ropivacaine added to clonidine: a randomized clinical trial

机译：罗哌卡因与可乐定合用的分娩镇痛：一项随机临床试验

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CONTEXT AND OBJECTIVE: Previous studies have led to speculation that the association between ropivacaine and clonidine might be more effective than ropivacaine alone. We examined the maternal-fetal effects of two pharmacological approaches: a low dose of ropivacaine or a lower dose of ropivacaine plus clonidine for epidural analgesia during labor. DESIGN AND SETTING: Prospective study at Department of Anesthesiology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista. METHODS: Thirty-two pregnant women in American Society of Anesthesiologists physical status I and II randomly underwent epidural analgesia using 15 ml of ropivacaine 0.125% (R group) or 15 ml of ropivacaine 0.0625% plus 75 μg clonidine (RC group). Pain intensity, sensory block level, latency time, motor block intensity, duration of labor analgesia and duration of epidural analgesia were evaluated. The newborns were evaluated using Apgar scores and the Amiel-Tison method (neurological and adaptive capacity score). RESULTS: There were no statistically significant differences between the groups regarding pain score, sensory block level, duration of epidural analgesia or Apgar score. The latency time, duration of labor analgesia and motor block were R group < RC group. The half-hour and two-hour neurological and adaptive capacity scores were higher in the R group. All of the R group newborns and 75% of the RC group newborns were found to be neurologically healthy at the 24-hour examination. RESULTS: There were no statistically significant differences between the groups regarding pain score, sensory block level, duration of epidural analgesia or Apgar score. The latency time, duration of labor analgesia and motor block were R group < RC group. The half-hour and two-hour neurological and adaptive capacity scores were higher in the R group. All of the R group newborns and 75% of the RC group newborns were found to be neurologically healthy at the 24-hour examination. CONCLUSION: Both low-dose ropivacaine and a lower dose plus clonidine relieved maternal pain during obstetric labor. Newborns of mothers who received only ropivacaine showed better neurological and adaptive capacity scores.
机译：背景与目的：先前的研究导致人们猜测，罗哌卡因与可乐定之间的关联可能比单独的罗哌卡因更有效。我们检查了两种药理学方法对产妇的胎儿作用：低剂量的罗哌卡因或小剂量的罗哌卡因加可乐定用于分娩时硬膜外镇痛。设计与环境：在Estadual Paulista大学Boculatu Faculdade医院进行了前瞻性研究。方法：美国麻醉医师学会的32名I和II型身体状况孕妇分别采用15 ml 0.125％的罗哌卡因（R组）或15 ml 0.0625％的罗哌卡因加75μg可乐定（RC组）进行硬膜外镇痛。评估疼痛强度，感觉阻滞水平，潜伏时间，运动阻滞强度，分娩镇痛持续时间和硬膜外镇痛持续时间。使用Apgar评分和Amiel-Tison方法（神经和适应能力评分）对新生儿进行评估。结果：两组之间在疼痛评分，感觉阻滞水平，硬膜外镇痛持续时间或Apgar评分方面无统计学差异。潜伏期，分娩镇痛时间和运动阻滞时间分别为R组

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