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首页> 外文期刊>Sao Paulo Medical Journal >Chronic myeloid leukemia (CML): prognostic factors and survival analysis
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Chronic myeloid leukemia (CML): prognostic factors and survival analysis

机译：慢性粒细胞白血病（CML）：预后因素和生存分析

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The prognostic value of different factors upon diagnosis of CML was analysed in 45 Philadelphia (Ph1)-positive patients. The median survival was 48 months. Univariate analysis showed 5 poor prognostic factors (male sex, under 45 years-old, bone marrow blasts greater than or equal to 10 percent, blood basophils greater than or equal to 6 percent and blood eosinophils greater than or equal to 6 percent) which provided for the development of a clinical staging system: Stage I with none or one factor and a two-year survival rate of 100 percent; Stage II with two or three factors and two-year survival of 72.2 percent; and Stage III with four or five factors and two-year survival of 0 percent (p = 0.00016). Multivariate survival analysis showed that combination of blood basophilia and bone marrow blasts had the strongest predictive relationship to survival time. We conclude that a combination of pretreatment factors identifies different risk subcategories in CML patients and is helpful in assessing the overall prognosis and the treatment approach.
机译：在45例费城（Ph1）阳性患者中分析了不同因素对CML诊断的预后价值。中位生存期为48个月。单因素分析显示有5个不良的预后因素（男性，年龄在45岁以下，骨髓胚细胞大于或等于10％，嗜碱性粒细胞大于或等于6％，血液嗜酸性粒细胞大于或等于6％）用于临床分期系统的开发：没有任何因素或只有一个因素且两年生存率为100％的I期;具有两个或三个因素的第二阶段，两年生存率为72.2％;第三阶段有四个或五个因素，两年生存率为0％（p = 0.00016）。多元生存分析表明，血嗜碱性粒细胞和骨髓母细胞的组合对生存时间具有最强的预测关系。我们得出的结论是，预处理因素的组合可识别CML患者的不同风险亚类，有助于评估总体预后和治疗方法。

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