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首页> 外文期刊>Sao Paulo Medical Journal >CEA as a prognostic index in colorectal cancer
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CEA as a prognostic index in colorectal cancer

机译：CEA作为结直肠癌预后指标

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INTRODUCTION: The carcinoembryonic antigen, CEA, is the tumor marker most used in colorectal patients, principally during follow up after radical surgery. High serum CEA level before surgery is often associated with worse prognosis, in some studies. OBJECTIVE: The purpose of this study was to evaluate the preoperative carcinoembryonic antigen levels (CEA) and the frequency of recurrence. MATERIAL AND METHODS: Eighty-three patients with colorectal cancer at Dukes stages A, B or C were evaluated retrospectively. The patients' follow up was at least two years or to death. CEA was detemined in serum by enzyme immunoassay (Sorin Biomedica), normal value 0-5ng/mI. RESULTS: Disease recurrence was observed in 32 patients (38.5%), 13 Dukes B and 19 Dukes C. Seventy five per cent of the patients with CEA higher than 10ng/ml relapsed and 80% of the patients without recurrence had normal CEA. Disease recurrence in patients with preoperative elevated CEA occurred during the first year of follow up in 56% of the patients. CONCLUSION: Although the tumor stage is today the most valuable prognostic variable in colorectal cancer, the preoperative CEA value can provide some additional information in the prognosis of the patient.
机译：引言：癌胚抗原CEA是结直肠癌患者中最常用的肿瘤标志物，主要是在根治性手术后的随访中。在一些研究中，术前血清CEA水平高通常与预后不良有关。目的：本研究旨在评估术前癌胚抗原水平（CEA）和复发频率。材料与方法：回顾性分析了Dukes A，B或C期的83例结直肠癌患者。患者的随访至少两年或死亡。通过酶免疫测定法（Sorin Biomedica）测定血清中的CEA，正常值为0-5ng / ml。结果：32例患者（38.5％），13例杜克B病和19例杜克C病复发。CEA高于10ng / ml的患者中有75％复发，而未复发的80％的患者CEA正常。术后第一年，术前CEA升高的患者发生疾病复发，占56％。结论：尽管今天的肿瘤分期是大肠癌中最有价值的预后变量，但术前CEA值可为患者的预后提供一些其他信息。

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