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首页> 外文期刊>Sao Paulo Medical Journal >Iron deficiency in blood donors
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Iron deficiency in blood donors

机译：献血者铁缺乏

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CONTEXT: Blood donation results in a substantial loss of iron (200 to 250 mg) at each bleeding procedure (425 to 475 ml) and subsequent mobilization of iron from body stores. Recent reports have shown that body iron reserves generally are small and iron depletion is more frequent in blood donors than in non-donors. OBJECTIVE: The aim of this study was to evaluate the frequency of iron deficiency in blood donors and to establish the frequency of iron deficiency in blood donors according to sex, whether they were first-time or multi-time donors, and the frequency of donations per year. DESIGN: From September 20 to October 5, 1999, three hundred blood donors from Santa Casa Hemocenter of S?o Paulo were studied. DIAGNOSTIC TESTS: Using a combination of biochemical measurements of iron status: serum iron, total iron-binding capacity, transferrin saturation index, serum ferritin and the erythrocyte indices. RESULTS: The frequency of iron deficiency in blood donors was 11.0%, of whom 5.5% (13/237) were male and 31.7% (20/63) female donors. The frequency of iron deficiency was higher in multi-time blood donors than in first-time blood donors, for male blood donors (7.6% versus 0.0%, P < 0.05) and female ones (41.5% versus 18.5%, P < 0.05). The frequency of iron deficiency found was higher among the male blood donors with three or more donations per year (P < 0.05) and among the female blood donors with two or more donations per year (P < 0.05). CONCLUSIONS: We conclude that blood donation is a very important factor for iron deficiency in blood donors, particularly in multi-time donors and especially in female donors. The high frequency of blood donors with iron deficiency found in this study suggests a need for a more accurate laboratory trial, as hemoglobin or hematocrit measurement alone is not sufficient for detecting and excluding blood donors with iron deficiency without anemia.
机译：背景：献血导致每次出血（425至475毫升）铁大量损失（200至250毫克），随后动员人体储存铁。最近的报告表明，献血者体内的铁储备通常很小，铁消耗比非献血者更为频繁。目的：本研究的目的是评估献血者中铁缺乏的频率，并根据性别（无论是初次还是多次献血者）确定献血者中铁缺乏的频率，以及献血的频率每年。设计：从1999年9月20日至10月5日，研究了圣保罗圣卡萨血液中心的300名献血者。诊断测试：结合生铁测量铁的状态：血清铁，总铁结合能力，转铁蛋白饱和指数，血清铁蛋白和红细胞指数。结果：献血者缺铁的频率为11.0％，其中男性为5.5％（13/237），女性为31.7％（20/63）。多次献血者中铁缺乏的频率高于第一次献血者，男性献血者（7.6％比0.0％，P <0.05）和女性献血者（41.5％比18.5％，P <0.05） 。在男性每年献血次数为三个或更多的献血者中，发现铁缺乏的频率更高（P <0.05），而在每年两次献血次数或更多为献血的女性献血者中（P <0.05）。结论：我们得出结论，献血是造成献血者铁缺乏的一个非常重要的因素，尤其是在多次供血者中，尤其是在女性献血者中。这项研究中发现的缺铁性献血者的高频率提示需要进行更准确的实验室试验，因为仅通过血红蛋白或血细胞比容测量不足以检测和排除无贫血的缺铁性献血者。

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