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首页> 外文期刊>Saudi Journal of Gastroenterology >Surgical management of gastric gastrointestinal stromal tumor: A single center experience
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Surgical management of gastric gastrointestinal stromal tumor: A single center experience

机译：胃胃肠道间质瘤的外科治疗：单中心经验

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Background/Aim: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Surgery remains the mainstay of curative treatment. Our objective is to evaluate the outcome of surgical treatment of primary gastric GIST. Materials and Methods: Between January 1997 and April 2008, thirty seven consecutive patients underwent resection for GISTs (35 patients with primary gastric GISTs and two patients with intestinal GISTs who were excluded from the study). These patients underwent upper endoscopy ± biopsy, barium meal and abdominal CT scan. Patients' demographics and clinical presentations were analyzed. Perioperative parameters measured included operative times, estimated blood loss, intraoperative finding, surgical techniques, morbidity and length of hospitalization. Recurrence and survival were also analyzed. Results: Of the 35 patients with gastric GISTs included in the study, 63% were female. The median age was 59 ± 14 years (range, 23 to 75 years). The primary presenting symptoms were bleeding and dyspepsia; 43% of these tumors were located mainly in the body of the stomach. Tumor size was < 10 cm in 80% of the patients. The average tumor size was 6.3 ±3.2 cm (range from 3 to 13 cm). Regarding the surgical management, 20 patients (57%) underwent gastric wedge resection, eight patients (23%) underwent partial gastrectomy and the remaining seven patients (20%) underwent total gastrectomy. Radical resections were found in 32 patients (91.5%) while palliative resections were found in three patients (8.5%). The resected lymph nodes were negative in 32 patients (91.5%). Recurrence was noted in three patients, with a median time to recurrence of 14.3 months (range, 7 to 28 months). The three- and five-years survival in patients who underwent wedge resection was 92% and 81%, respectively, where it was 95% and 87%, respectively, in patients who underwent gastrectomy (either partial or total). There were no major intraoperative complications or mortalities. Conclusion: Complete surgical resection either through wedge resection or gastrectomy with negative margins remains the gold standard treatment in the management of patients with primary resectable gastric GISTs.
机译：背景/目的：胃肠道间质瘤（GIST）是胃肠道最常见的间质肿瘤。手术仍然是治疗的主要手段。我们的目的是评估原发性胃GIST的手术治疗结果。材料和方法：1997年1月至2008年4月，连续37例患者接受了GIST切除术（35例原发性胃GIST患者和2例肠道GIST患者被排除在研究之外）。这些患者接受了上内镜检查±活检，钡餐和腹部CT扫描。分析了患者的人口统计学和临床​​表现。测量的围手术期参数包括手术时间，估计失血量，术中发现，手术技术，发病率和住院时间。还分析了复发和生存。结果：纳入研究的35例胃GIST患者中，女性占63％。中位年龄为59±14岁（范围23至75岁）。主要表现为出血和消化不良。这些肿瘤中有43％主要位于胃部。 80％的患者肿瘤大小小于10厘米。平均肿瘤大小为6.3±3.2 cm（3至13 cm）。关于手术管理，有20例（57％）进行了胃楔形切除术，8例（23％）进行了部分胃切除术，其余7例（20％）进行了全胃切除术。根治性切除32例（91.5％），姑息性切除3例（8.5％）。切除的淋巴结阴性32例（91.5％）。 3例患者复发，中位复发时间为14.3个月（范围7至28个月）。进行楔形切除的患者的三年和五年生存率分别为92％和81％，而接受胃切除术（部分或全部）的患者分别为95％和87％。术中无重大并发症或死亡。结论：通过楔形切除或负切缘的胃切除术进行完整的手术切除仍是原发性可切除胃GIST患者治疗的金标准治疗。

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