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首页> 外文期刊>Saudi Journal of Gastroenterology >Variceal band ligation in the prevention of variceal bleeding: A multicenter trial
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Variceal band ligation in the prevention of variceal bleeding: A multicenter trial

机译：静脉曲张结扎术预防静脉曲张破裂出血：一项多中心试验

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Background/Aim: Variceal bleeding is a life-threatening complication of portal hypertension with a high probability of recurrence. Treatment to prevent first bleeding or rebleeding is mandatory. The study has been aimed at investigating the effectiveness of endoscopic band ligation in preventing upper gastrointestinal bleeding in patients with portal hypertension and to establish the clinical outcome of patients. Patients and Methods: We analyzed in a multicenter trial, the efficacy and side effects of endoscopic band ligation for the primary and secondary prophylaxis of esophageal variceal bleeding. We assigned 603 patients with portal hypertension who were hospitalized to receive treatment with endoscopic ligation. Sessions of ligation were repeated every two to three weeks until the varices were eradicated. The primary end point was recurrent bleeding. Results: The median follow-up period was 32 months. A total of 126 patients had recurrent bleeding. All episodes were related to portal hypertension and 79 to recurrent variceal bleeding. There were major complications in 51 patients (30 had bleeding esophageal ulcers). Seventy-eight patients died, 26 deaths were related to variceal bleeding and 1 to bleeding esophageal ulcers. Conclusions: A great improvement in the prevention of variceal bleeding has emerged over the last years. However, further therapeutic options that combine higher efficacy, better tolerance and fewer side effects are needed.
机译：背景/目的：静脉曲张破裂出血是危及生命的门脉高压并发症，极有可能复发。必须进行治疗以防止首次出血或再出血。这项研究的目的是调查内镜带结扎在预防门静脉高压症患者上消化道出血的有效性并确定患者的临床结局。患者和方法：我们在一项多中心试验中分析了内镜带结扎术对食管静脉曲张破裂出血的一级和二级预防的功效和副作用。我们分配了603例门静脉高压症患者，这些患者住院接受内镜结扎治疗。每两到三周重复一次结扎手术，直到根除静脉曲张。主要终点是复发性出血。结果：中位随访期为32个月。共有126例患者复发出血。所有发作均与门静脉高压有关，而79例与复发性静脉曲张破裂出血有关。 51例患者有重大并发症（30例食管溃疡出血）。 78例患者死亡，其中26例死亡与静脉曲张破裂出血有关，1例与食管溃疡出血有关。结论：近年来，预防静脉曲张破裂出血已取得了很大进步。然而，需要结合更高功效，更好耐受性和更少副作用的其他治疗选择。

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