...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Our Dermatology Online >Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats
【24h】

Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats

机译：维生素E亚型对糖尿病大鼠原发性皮肤伤口愈合的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Impaired wound healing events is a common complication in diabetes. One of the effective nutritionalantioxidant on skin wound healing is vitamin E which contains saturated tocopherol and unsaturated tocotrienolforms. This present study is designed to explore the effect of different vitamin E isoforms on stitched skin wound inboth healthy and diabetic rats. Materials and Methods: Forty eight albino rats were divided into eight groups; healthycontrol, diabetic control, healthy treated (d-α-tocopherol, d-δ-TRF and co-administrated) and diabetic treated (d-α-tocopherol, d-δ-TRF and co-administrated). Diabetes was induced through single subcutaneous injection of alloxanat the dose of 100 mg/kg. Treated groups were administered d-a-tocopherol (200 mg/kg), d-δ-TRF (200 mg/kg) andco-administration (100 mg/kg of these two compounds each) orally and daily for three weeks. A horizontal skin incisionwas made on right mid-thigh region at 2.95 ± 0.17cm in length and wound was closed with an absorbable suture.Results: Histopathological and histomorphological results at the end of 3rd week revealed that the d-δ-TRF treatedgroups promote the regeneration and reorganization of epidermal and dermal components in healing of primaryintention more effectively than the d-α-tocopherol and co-administrated groups. Conclusion: It is concluded thatamong different vitamin E isoforms the d-δ-TRF appears to be a more effective nutritional antioxidant on skin woundhealing in both healthy and diabetics.
机译：简介：伤口愈合事件受损是糖尿病的常见并发症。对皮肤伤口愈合有效的营养抗氧化剂之一是维生素E，它含有饱和的生育酚和不饱和的生育三烯酚形式。本研究旨在探讨健康和糖尿病大鼠体内不同维生素E亚型对缝合皮肤伤口的影响。材料与方法：48只白化病大鼠分为8组。健康对照，糖尿病对照，健康治疗（d-α-生育酚，d-δ-TRF和共同给药）和糖尿病治疗（d-α-生育酚，d-δ-TRF和共同给药）。通过单次皮下注射Alloxanat剂量为100 mg / kg诱导糖尿病。给治疗组口服和每天口服d-α-生育酚（200 mg / kg），d-δ-TRF（200 mg / kg）和共同给药（这两种化合物各100 mg / kg），持续三周。在右大腿中部做一个水平的皮肤切口，长度为2.95±0.17cm，并用可吸收的缝合线缝合伤口。结果：第3周末的组织病理学和组织形态学结果显示，d-δ-TRF治疗组促进了皮肤的生长。表皮和真皮成分在原发性意图愈合中的再生和重组比d-α-生育酚和共同给药组更有效。结论：结论是，在健康和糖尿病患者中，不同的维生素E亚型中的d-δ-TRF似乎是一种更有效的营养抗氧化剂，可促进皮肤伤口愈合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号