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首页> 外文期刊>Sao Paulo Medical Journal >Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation
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Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation

机译：同种异体造血干细胞移植后人白细胞抗原与移植物抗宿主病发生的关系

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CONTEXT AND OBJECTIVE: Graft-versus-host disease (GVHD) is one of the complications following allogenic stem cell transplantation. This study investigated an association between human leukocyte antigen (HLA) and the occurrence of acute and chronic GVHD in patients who had received stem cell transplantations from HLA-identical siblings. DESIGN AND SETTING: Retrospective study at Hematology and Hemotherapy Center, Universidade Estadual de Campinas (Unicamp). METHODS: The participants were 176 patients whose first transplant was between 1997 and 2009. HLA genotyping was performed serologically and using the polymerase chain reaction with specific primer sequence. RESULTS: Acute GVHD was positively associated with HLA-A10 (P = 0.0007), HLA-A26 (P = 0.002), B55 (P = 0.001), DRB1*15 (P = 0.0211) and DQB1*05 (P = 0.038), while HLA-B16 (P = 0.0333) was more frequent in patients without acute GVHD. Chronic GVHD was positively associated with HLA-A9 (P = 0.01) and A23 (P = 0.0292) and negatively with HLA-A2 (P = 0.0031) and B53 (P = 0.0116). HLA-B35 (P = 0.0373), B49 (P = 0.0155) and B55 (P = 0.0024) were higher in patients with acute GVHD grade 3 or above, than in other patients. In patients with extensive chronic GVHD, HLA-A9 (P = 0.0004), A24 (P = 0.0059) and A26 (P = 0.0411) were higher than in other patients, while HLA-A2 was lower (P = 0.0097). CONCLUSION: This study suggests that HLA can influence the incidence and severity of acute and chronic GVHD. However, a study with a better design and more patients will be needed to confirm these results.
机译：背景与目的：移植物抗宿主病（GVHD）是同种异体干细胞移植后的并发症之一。这项研究调查了人类白细胞抗原（HLA）与接受自HLA相同兄弟姐妹干细胞移植的患者中急性和慢性GVHD发生之间的关联。设计与地点：在Estcampual de Campinas大学（Unicamp）血液学和血液治疗中心进行回顾性研究。方法：参与者为176例患者，他们的首次移植时间为1997年至2009年。HLA基因分型通过血清学方法进行，并使用具有特定引物序列的聚合酶链反应。结果：急性GVHD与HLA-A10（P = 0.0007），HLA-A26（P = 0.002），B55（P = 0.001），DRB1 * 15（P = 0.0211）和DQB1 * 05（P = 0.038）正相关，而没有急性GVHD的患者中HLA-B16（P = 0.0333）更为频繁。慢性GVHD与HLA-A9（P = 0.01）和A23（P = 0.0292）正相关，与HLA-A2（P = 0.0031）和B53（P = 0.0116）负相关。急性GVHD 3级或更高的患者的HLA-B35（P = 0.0373），B49（P = 0.0155）和B55（P = 0.0024）高于其他患者。在患有广泛性慢性GVHD的患者中，HLA-A9（P = 0.0004），A24（P = 0.0059）和A26（P = 0.0411）高于其他患者，而HLA-A2则较低（P = 0.0097）。结论：本研究提示HLA可影响急，慢性GVHD的发生率和严重程度。但是，需要进行更好的设计和更多患者的研究来证实这些结果。

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