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首页> 外文期刊>Sao Paulo Medical Journal >Vascular endothelial growth factor, endostatin levels and clinical features among patients with ulcerative colitis and irritable bowel syndrome and among healthy controls: a cross-sectional analytical study
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Vascular endothelial growth factor, endostatin levels and clinical features among patients with ulcerative colitis and irritable bowel syndrome and among healthy controls: a cross-sectional analytical study

机译：溃疡性结肠炎和肠易激综合征患者以及健康对照者的血管内皮生长因子，内皮抑素水平和临床特征：一项横断面分析研究

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ABSTRACT BACKGROUND: Increased angiogenetic activity in inflammatory bowel disease (IBD) has been shown in previous studies. The aim of this study was to evaluate the relationship of serum vascular endothelial growth factor (VEGF) and endostatin levels with clinical features and mucosal expression in patients with ulcerative colitis (UC). DESIGN AND SETTING: Cross-sectional analytical study conducted in a tertiary-level public hospital. METHODS: Serum VEGF and endostatin levels were determined in 82 individuals: 39 with UC, 28 with irritable bowel syndrome (IBS) and 15 healthy controls (HCs), using enzyme-linked immunosorbent assays (ELISA). VEGF and endostatin expressions were studied using immunohistochemistry (IHC). RESULTS: Mean serum VEGF and endostatin levels were significantly higher in patients with UC than in patients with IBS and in HCs (511.9 ± 377.5 pg/ml, 305.0 ± 121.42 pg/ml and 36.1 ± 40.6 pg/ml; P = 0.001 for VEGF; and 155.50 ± 59.8 ng/ml, 116.9 ± 23.8 ng/ml and 102.2 ± 22.4 ng/ml; P 0.001 for endostatin, respectively). There was a positive correlation between serum VEGF and endostatin levels (r = 0.422; P 0.01). Mean H-scores for VEGF expression were higher in the active UC group than in the inactive UC and IBS groups, in the stroma, endothelium and epithelium. Mean H-scores for endostatin expression were higher in the active UC group than in the inactive UC and IBS groups, in the stroma and endothelium. There was no endostatin expression in the epithelium. CONCLUSION: Increased endostatin appears to be a defensive reaction to increased VEGF in patients with UC.
机译：摘要背景：以前的研究表明，炎症性肠病（IBD）的血管生成活性增加。这项研究的目的是评估溃疡性结肠炎（UC）患者的血清血管内皮生长因子（VEGF）和内皮抑素水平与临床特征和粘膜表达的关系。设计与环境：在一家三级公立医院进行的横断面分析研究。方法：采用酶联免疫吸附试验（ELISA）测定了82例患者的血清VEGF和内皮抑素水平：UC患者39例，肠易激综合征（IBS）28例，健康对照者15例（HCs）。使用免疫组织化学（IHC）研究了VEGF和内皮抑素的表达。结果：UC患者的平均血清VEGF和内皮抑素水平显着高于IBS患者和HCs患者（511.9±377.5 pg / ml，305.0±121.42 pg / ml和36.1±40.6 pg / ml; VEGF的P = 0.001 ;和155.50±59.8 ng / ml，116.9±23.8 ng / ml和102.2±22.4 ng / ml;内皮抑素的P <0.001）。血清VEGF与内皮抑素水平呈正相关（r = 0.422; P <0.01）。在活性UC组中，在基质，内皮和上皮中，​​VEGF表达的平均H分数高于无活性UC和IBS组。在活动性UC组中，基质和内皮中内皮抑素表达的平均H分数高于非活动性UC和IBS组。上皮中没有内皮抑素表达。结论：内皮抑素增加似乎是UC患者VEGF增加的防御反应。

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