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首页> 外文期刊>Sao Paulo Medical Journal >Pituitary macroadenoma presenting as a nasal tumor: case report
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Pituitary macroadenoma presenting as a nasal tumor: case report

机译：垂体腺瘤表现为鼻肿瘤：病例报告

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CONTEXT: Pituitary macroadenomas are rare intracranial tumors. In a few cases, they may present aggressive behavior and invade the sphenoid sinus and nasal cavity, causing unusual symptoms. In this paper, we report an atypical case of pituitary adenoma presenting as a nasal mass.CASE REPORT: The patient was a 44-year-old woman who had had amenorrhea and galactorrhea for ten months, with associated nasal obstruction, macroglossia and acromegaly. Both growth hormone and prolactin levels were increased. Magnetic resonance imaging showed a large mass originating from the lower surface of the pituitary gland, associated with sella turcica erosion and tumor extension through the sphenoid sinus and nasal cavity. Histopathological analysis demonstrated a chromophobe pituitary adenoma with densely packed rounded epithelial cells, with some atypias and rare mitotic figures. There was no evidence of metastases.CONCLUSION: Macroadenoma invading the nasal cavity is a rare condition and few similar cases have been reported in the literature. This study contributes towards showing that tumor extension to the sphenoid sinus and nasopharynx needs to be considered and investigated in order to make an early diagnosis when atypical symptoms like nasal obstruction are present.
机译：背景：垂体大腺瘤是罕见的颅内肿瘤。在少数情况下，它们可能表现出攻击性行为并侵入蝶窦和鼻腔，引起异常症状。在本文中，我们报告了一个非典型的垂体腺瘤鼻腔肿块病例。病例报告：该患者是一名44岁的女性，患有闭经和溢乳持续10个月，伴有鼻塞，巨眼和肢端肥大。生长激素和催乳激素水平均增加。磁共振成像显示较大的肿块来自垂体下表面，与蝶鞍糜烂和通过蝶窦和鼻腔的肿瘤扩展有关。组织病理学分析表明，发色垂体垂体腺瘤具有密集的圆形上皮细胞，具有一些非典型性和少见的有丝分裂体。结论：结论：侵袭鼻腔的大腺瘤是一种罕见的疾病，文献报道的病例很少。这项研究有助于表明，当存在非典型症状（如鼻塞）时，需要考虑和调查肿瘤向蝶窦和鼻咽的扩展，以便进行早期诊断。

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