...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sao Paulo Medical Journal >Treatment of children and adolescents with hemangioma using propranolol: preliminary results from a retrospective study
【24h】

Treatment of children and adolescents with hemangioma using propranolol: preliminary results from a retrospective study

机译：普萘洛尔治疗儿童和青少年血管瘤的回顾性研究的初步结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT AND OBJECTIVE: Hemangiomas are the commonest vascular tumors during childhood. In 2008, the effect of propranolol for treating capillary hemangiomas was demonstrated. Other similar results followed, showing that it rapidly reduces lesion volume. The objective here was to evaluate children and adolescents with hemangiomas that were treated with propranolol. DESIGN AND SETTING: Retrospective study, conducted in a children's hospital. METHODS : Patients aged 0-19 years with or without previous treatment, who were treated between January 2009 and December 2010, were included. The response was assessed by comparing the lesion appearance between the start of treatment and the last consultation. We considered partial or complete responses as the response to treatment. RESULTS : Sixty-nine patients with a median follow-up of 11 months (mean age: 31 months) were included. Of these, 58 patients were recently diagnosed and 11 had had previous treatment. A response (partial or complete) was seen in 60 patients (87%). Among the capillary hemangioma cases, responses were seen in 50 out of 53 (94%), while in other lesion types, it was 10 out of 16 (63%) (P = 0.3; chi-square). Responses in patients less than one year of age were seen in 37 out of 38 (97%), whereas in those over one year of age, in 23 out of 31 (74%) (P = 0.4; chi-square). Side effects were uncommon and mild. CONCLUSIONS: Propranolol seemed to be effective for treatment of hemangiomas in children and adolescents, and not just in the proliferative stage, with responses in almost all the patients.
机译：背景与目的：血管瘤是儿童时期最常见的血管肿瘤。 2008年，证明了普萘洛尔治疗毛细血管瘤的效果。随后的其他类似结果表明，它可以迅速减少病变体积。此处的目的是评估经普萘洛尔治疗的血管瘤儿童和青少年。设计与地点：回顾性研究，在儿童医院进行。方法：纳入2009年1月至2010年12月期间接受或不接受先前治疗的0-19岁患者。通过比较治疗开始和最后一次咨询之间的病变外观来评估反应。我们认为部分或完全反应是对治疗的反应。结果：69例患者的中位随访时间为11个月（平均年龄：31个月）。其中，最近被诊断出58例患者，其中11例曾经接受过治疗。 60例患者中有反应（部分或完全）（87％）。在毛细血管血管瘤病例中，有53例中有50例（94％）可见反应，而在其他病变类型中，有16例中有10例（63％）可见反应（P = 0.3;卡方）。在38岁以下的患者中，未满1岁的患者有反应（97％），而在1岁以上的患者中，有31％的患者中有反应（74％）（P = 0.4;卡方）。副作用不常见且轻微。结论：普萘洛尔似乎对儿童和青少年的血管瘤治疗有效，而不仅仅是在增殖期，几乎所有患者均有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号