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首页> 外文期刊>Sao Paulo Medical Journal >Hairy cell leukemia: a histo-cytochemical and ultra-structural study
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Hairy cell leukemia: a histo-cytochemical and ultra-structural study

机译：毛细胞白血病：组织细胞化学和超结构研究

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We studied five patients with hairy cell leukemia (HCL) diagnosed within the last ten years at the Department of Hematology of Universidade Federal de S?o Paulo - Escola Paulista de Medicina. Our purpose was to analyze the value of transmission electron microscopy (TEM) by comparing this method with the conventional ones. At diagnosis, patients presented weight loss, spleen enlargement and hairy cells (HC) in peripheral blood and bone marrow slides. HC was characterized by morphology and tartrate test resistance in the acid phosphatase reaction (TRAP). At the evaluation time, the amount of HC ranged from 1% to 85% of WBC count. All patients, except two, had phenotype B. In these last two, TRAP as well as phenotype B could not be documented due to low HC numbers in their exams. Cytoplasmatic projections and the absence of lamellar ribosomic complex were the most frequent ultrastructural findings, even in those patients with the lowest HC numbers. Based on these features, TEM is an efficient method for searching for HC at HCL diagnosis and during the course of the disease.
机译：我们研究了在最近十年中在圣保罗联邦大学-埃斯科拉·保利斯塔·德·梅迪西纳的血液学部门诊断出的五名毛细胞白血病（HCL）患者。我们的目的是通过与传统方法进行比较来分析透射电子显微镜（TEM）的价值。诊断时，患者出现体重减轻，脾脏肿大和外周血和骨髓切片中的毛细胞（HC）。 HC的特征在于酸性磷酸酶反应（TRAP）中的形态和酒石酸测试抗性。在评估时，HC含量为白细胞计数的1％至85％。除两名患者外，所有患者均具有B型。在最近的两名患者中，由于检查中的HC值低，无法记录TRAP和B型。细胞质投射和层状核糖体复合物缺失是最常见的超微结构发现，即使在那些HC数最低的患者中也是如此。基于这些特征，TEM是在HCL诊断和疾病过程中寻找HC的有效方法。

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