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首页> 外文期刊>Saudi Journal of Biological Sciences >The protective role of parsley extract against vincristine mutagenicity in Drosophila melanogaster
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The protective role of parsley extract against vincristine mutagenicity in Drosophila melanogaster

机译：欧芹提取物对黑腹果蝇中长春新碱致突变性的保护作用

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In this study, Drosophila melanogaster males were treated with parsley plant extract and the anticancer drug vincristine (VCR) singly and in combined treatments (pre, co and post-treatments) to detect the mutagenic effects by using sex-linked recessive lethal test (SLRL) and estimation of cholinesterase enzyme (ChE) activities in order to compare the sensitivity of the two test systems. A wild type strain Oregon-R (Or-R) male flies of D. melanogaster were reared on a medium containing one concentration of each of VCR and parsley (4ml/100ml medium) in each single and combined treatment. Also the activity of ChE was estimated in some insects of the two generations: F1 females, F2 bar eye females (heterozygous) and F2 wild types males. The results indicate that both of parsley and vincristine did not cause significant increases of SLRL test in either the single or combined treatments. In contrast, estimation of ChE activities showed significant increase in all the broods within single and combination treatments, except female of the second generation of spermatid brood which treated with parsley and VCR at the same time. It is concluded that enzyme estimation is more sensitive than SLRL test for detection the mutagenic effect for parsley's extract and vincristine.
机译：在这项研究中，果蝇雄性果蝇分别用欧芹植物提取物和抗癌药长春新碱（VCR）进行了处理，并在联合处理中（治疗前，联合和后处理）通过使用性相关隐性致命试验（SLRL）来检测致突变作用）并估算胆碱酯酶（ChE）活性，以比较两个测试系统的敏感性。在每种单次和联合处理中，将黑腹果蝇的野生型Oregon-R（Or-R）雄性果蝇饲养在含有一种浓度的VCR和欧芹的培养基（4ml / 100ml培养基）上。还估计了两代昆虫中ChE的活性：F1雌性，F2直眼雌性（杂合）和F2野生型雄性。结果表明，无论是单一处理还是联合处理，欧芹和长春新碱均不会引起SLRL测试的显着增加。相比之下，对ChE活性的估计显示，在一次和联合处理中，除第二代精子母细胞的雌性同时用香菜和VCR处理外，所有亲子的显着增加。结论是酶估计比SLRL测试更灵敏，可以检测出香菜提取物和长春新碱的致突变作用。

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