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首页> 外文期刊>Saudi Journal of Biological Sciences >Effect of cervus and cucumis polypeptide combined with zoledronic acid on bone metabolic biochemical markers in glucocorticoids – Induced osteoporosis patients
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Effect of cervus and cucumis polypeptide combined with zoledronic acid on bone metabolic biochemical markers in glucocorticoids – Induced osteoporosis patients

机译：子宫颈和瓜皮多肽联合唑来膦酸对糖皮质激素诱导骨质疏松症患者骨代谢生化指标的影响

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Objective To investigate the effect of cervus and cucumis polypeptide combined with zoledronic acid on bone metabolic biochemical markers in glucocorticoids - induced osteoporosis patients. Methods A total of 100 patients with glucocorticoids - induced osteoporosis admitted to our hospital from January 2015 to June 2017 were enrolled in this study. Patients were divided into observation group and control group by random number table method, 50 cases in each group. Patients in the observation group were treated with deer melon polypeptide in combination with zoledronic acid, and patients in the control group were treated with zoledronic acid alone. The patients in both groups were treated for 2?months. The changes of bone mineral density (BMD) and biochemical markers of bone metabolism in lumbar vertebrae L1-4, left femoral neck and large trochanter were analyzed before and after treatment. Results The pre- BMD at lumbar spine Lsub1-4/sub, left femoral neck and great trochanter had no statistic difference ( P ??0.05), the BMD at each sites improved after treatment, and the difference were statistical before and after treatment ( P? ?0.05). BMD at above sites of two groups after treatment had statistical difference ( P? ?0.05), and the BMD at lumbar spine Lsub1-4/sub, left femoral neck and great trochanter in the observation group was higher than that of the control group. There were no significant differences in PTH, 25-(OH)D3, TRACP, β-CTX and BGP levels between the two groups before treatment (P??0.05). The levels of 25-(OH)D3, TRACP, β-CTX and BGP in the two groups were significantly improved after treatment (P??0.05), and the levels of PTH, TRACP and β-CTX in the observation group were significantly lower than those in the control group. The levels of 25-(OH) D3 and BGP were significantly higher than those of the control group (P??0.05). Conclusion The cervus and cucumis polypeptide combined with zoledronic acid can improve the BMD at lumbar spine Lsub1-4/sub, left femoral neck and great trochanter, and ameliorate the bone metabolic biochemical markers for patients with glucocorticoids - induced osteoporosis.
机译：目的探讨宫颈和瓜皮多肽联合唑来膦酸对糖皮质激素性骨质疏松症患者骨代谢生化指标的影响。方法选择2015年1月至2017年6月期间收治的100例糖皮质激素引起的骨质疏松症患者作为研究对象。采用随机数字表法将患者分为观察组和对照组，每组50例。观察组患者接受鹿瓜多肽联合唑来膦酸治疗，对照组患者接受唑来膦酸治疗。两组患者均治疗2个月。分析治疗前后腰椎L1-4，左股骨颈和大转子的骨密度和骨代谢的生化指标。结果腰椎L 1-4 ，左股骨颈和大转子的前BMD无统计学差异（P≥0.05），治疗后各部位BMD均改善，且差异有统计学意义（P <0.05）。治疗前后均具有统计学意义（P <0.05）。两组治疗后以上部位骨密度有统计学差异（P <0.05），观察组腰椎L 1-4 ，股骨颈和大转子的骨密度较高。比对照组。两组治疗前PTH，25-（OH）D3，TRACP，β-CTX和BGP水平无显着性差异（P≥0.05）。两组治疗后25-（OH）D3，TRACP，β-CTX和BGP的水平明显改善（P 0.05），观察组的PTH，TRACP和β-CTX的水平分别为：明显低于对照组。 25-（OH）D3和BGP的水平显着高于对照组（P 0.05）。结论宫颈黄瓜多肽与唑来膦酸结合可改善腰椎L 1-4 ，股骨颈和大转子骨的BMD，并改善糖皮质激素诱发的骨质疏松症患者的骨代谢生化指标。 。

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