...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Saudi Journal of Biological Sciences >Interfering PLD1-PED/PEA15 interaction using self-inhibitory peptides: An in silico study to discover novel therapeutic candidates against type 2 diabetes
【24h】

Interfering PLD1-PED/PEA15 interaction using self-inhibitory peptides: An in silico study to discover novel therapeutic candidates against type 2 diabetes

机译：使用自抑制肽干扰PLD1-PED / PEA15相互作用：一项计算机研究，发现了针对2型糖尿病的新型治疗药物

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diabetes type 2 (T2D) is a very complex disorder with a large number of cases reported worldwide. There are several reported molecular targets which are being used towards drug design. In spite of extensive research efforts, there is no sure shot treatment available. One of the major reasons for this failure or restricted success in T2D research is the identification of a major/breakthrough therapeutic target responsible for the progression of T2D. It has been well documented that one of the major causes mediating the insulin resistance is the interaction of PLD1 with PED/PEA15. Herein, we have performed in silico experiments to investigate the interaction between PLD1 with PED/PEA15. Furthermore, this study has explored pertinent molecular interactions involving the self-derived peptides. The peptides identified in this study are found to be capable of restricting the interaction of these two proteins. Accordingly, the study suggests that the “self-derived peptides” could be used as promising therapeutic candidate(s) against T2D.
机译：2型糖尿病（T2D）是一种非常复杂的疾病，全世界范围内都有大量病例报道。有几种报道的分子靶标正用于药物设计。尽管进行了广泛的研究，但尚无确定的击球治疗方法。在T2D研究中失败或限制成功的主要原因之一是确定了导致T2D进展的主要/突破性治疗靶标。已有大量文献证明，介导胰岛素抵抗的主要原因之一是PLD1与PED / PEA15的相互作用。在这里，我们已经进行了计算机实验，以研究PLD1与PED / PEA15之间的相互作用。此外，这项研究探索了涉及自衍生肽的相关分子相互作用。发现在这项研究中鉴定的肽能够限制这两种蛋白质的相互作用。因此，该研究表明“自衍生肽”可用作抗T2D的有希望的治疗候选物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号