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首页> 外文期刊>Our Dermatology Online >Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population
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Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

机译：干扰素γ基因多态性是埃及人群样本中某些过敏性疾病（过敏性皮肤病和过敏性结膜炎）的标志

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Introduction: Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur to normally harmless environmental substances known as allergens; these reactions are acquired, predictable, and rapid. Allergy is one of four forms of hypersensitivity and is called type I (or immediate) hypersensitivity. Aim: To Analyze the allelic distribution of interferon gam ma gene polymorphism 874A>T in some allergic skin diseases and allergic conjunctivitis. Material and Methods: This study included 300 Egyptian individual, divided into 100 patients with allergic skin diseases, 100 patients with allergic conjunctivitis and 100 healthy individual were taken as controls. Eosinophil count was estimated, Total IgE level was measured by ELISA technique, Nuclear DNA extracted from peripheral leukocytes and interferon gam ma gene polymorphism 874A>T detected by Amplification Refractory Mutation system (ARMS-PCR).Results: In the Skin allergic group, the (AT) genotype and the (TT) genotype were the most com mon (both are 45%), while in the Conjunctivitis group and the normal control groups the (TT) genotype was the most com mon (60% and 90% respectively). Moreover, there was statistically significant difference in the distribution of the IFN-γ genotypes at position 874 among the studied groups as compared all together. Conclusions: The IFN-. gene polymorphism at position +874 increases susceptibility to atopic diseases, and the identification of variants of the IFN-. gene and their role in the development of atopic diseases provides a focus for the development of novel diagnostic and therapeutic strategies.
机译：简介：过敏是免疫系统的超敏性疾病。过敏反应发生于通常被称为过敏原的无害环境物质。这些反应是获得性，可预测的和快速的。过敏症是超敏反应的四种形式之一，被称为I型（即刻）超敏反应。目的：分析干扰素gam ma基因多态性874A> T在一些过敏性皮肤病和过敏性结膜炎中的等位基因分布。材料与方法：本研究纳入300例埃及人，分为100例过敏性皮肤病患者，100例过敏性结膜炎患者和100例健康个体。估计嗜酸性粒细胞计数，通过ELISA技术测定总IgE水平，通过扩增难治性突变系统（ARMS-PCR）检测外周血白细胞核DNA和干扰素gam ma基因多态性874A> T。结果：皮肤过敏组（AT）基因型和（TT）基因型最为常见（均为45％），而在结膜炎组和正常对照组中，（TT）基因型最为常见（分别为60％和90％） 。此外，在所有研究组之间，相比而言，在874位的IFN-γ基因型分布的分布具有统计学上的显着差异。结论：IFN-。 +874位点的基因多态性增加了对特应性疾病的敏感性，并鉴定了IFN-的变体。基因及其在特应性疾病发展中的作用为新型诊断和治疗策略的发展提供了焦点。

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