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Chiral switching in biomineral suprastructures induced by homochiral l-amino acid

机译：同手性l-氨基酸诱导的生物矿物超结构中的手性转换

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How homochiral l -biomolecules in nature induce a chiral switch in biomineralized architectures is unknown, although chiral switching is common in many calcium carbonate–hardened structures found in marine and terrestrial organisms. We created hierarchically organized, chiral biomineral structures of calcium carbonate, whose chirality can be switched by a single l -enantiomer of an amino acid. The control of this chiral switching involves two stages: a calcium carbonate (vaterite) platelet layer inclination stage, followed by a platelet layer rotation stage, the latter stage being responsible for successional chiral switching events within the biomineralized structures. The morphology of the synthesized chiral vaterite structures remarkably resembles pathologic chiral vaterite otoconia found in the human inner ear. In general, these findings describe how a single-enantiomer amino acid might contribute to biomineral architectures having more than one chirality as is commonly seen in biology, and more specifically, they suggest how pathologic chiral malformations may arise in humans.
机译：尽管在海洋和陆地生物中发现的许多碳酸钙硬化结构中，手性转换很常见，但自然中的手性1-生物分子如何在生物矿化结构中引起手性转换是未知的。我们创建了碳酸钙的分级组织的手性生物矿物结构，其手性可以通过氨基酸的单个1-对映体来切换。该手性转换的控制涉及两个阶段：碳酸钙（球ate石）血小板层倾斜阶段，随后是血小板层旋转阶段，后一阶段负责生物矿化结构内的连续手性转换事件。合成的手性球ate石结构的形态非常类似于在人类内耳中发现的病理性手性球ate石耳科。总的来说，这些发现描述了单一对映体氨基酸如何对生物学上常见的具有多个手性的生物矿物结构产生影响，更具体地说，它们暗示了人类可能会出现病理性手性畸形。

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