• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oxidative Medicine and Cellular Longevity >Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor
【24h】

Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

机译：低水平激光疗法可减少涉及P2X7受体的慢性阻塞性肺疾病实验模型中的肺部炎症。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm2) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.
机译：慢性阻塞性肺疾病（COPD）是一种进行性疾病，其特征为不可逆的气流受限，气道炎症和重塑以及肺泡间隙增大。 COPD在全球死亡的前五名中排名第一，并带来了很高的经济成本。但是，有一些预防措施可以降低发生COPD的风险。低水平激光疗法（LLLT）是一种新的有效疗法，具有非常低的成本并且没有副作用。因此，我们的目的是在COPD实验模型中研究LLLT是否能减少肺部改变。将C57BL / 6小鼠抽烟75天（2x /天）。吸烟60天后，将治疗组接受LLLT（660 nm，30 mW和3 J / cm2的二极管激光）治疗15天，并安乐死以进行肺的形态和功能分析。我们的研究结果表明，LLLT显着减少了支气管肺泡灌洗液（BALF）中炎性细胞的数量以及促炎细胞因子的分泌，例如IL-1β，IL-6和TNF-α。我们还观察到LLLT减少了胶原蛋白沉积以及嘌呤能P2X7受体的表达。另一方面，LLLT增加了IL-10的释放。因此，LLLT可以作为COPD肺炎性疾病的有前途的治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号