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首页> 外文期刊>Saudi Journal of Anaesthesia >Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block
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Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block

机译：右美托咪定联合布比卡因在神经内给药对股骨坐骨神经阻滞的影响

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Background and Aim: Perineural administration of dexmedetomidine, a α2-adrenoceptor agonist, prolongs the duration of analgesia. We hypothesized that adding dexmedetomidine to bupivacaine would prolong postoperative analgesia after below knee surgery. Materials and Methods: After ethical approval, 60 patients scheduled for below knee surgery under combined femoral-sciatic nerve block were randomly allocated into two groups to have their block performed using bupivacaine 0.5% alone (group B) or bupivacaine 0.5% combined with 100 μg bupivacaine-dexmedetomidine (group BD). Motor and sensory block onset times; durations of blockades and analgesia were recorded. Results: Sensory and motor block onset times were shorter by 20% in group BD than in group B ( P < 0.01). Sensory and motor blockade durations were longer in group BD (+45% and +40%, respectively) than in group B ( P < 0.01). Duration of analgesia was longer in group BD by 75% than in group B ( P < 0.01). Systolic, diastolic arterial blood pressure levels, and heart rate were significantly less in group BD, six patients in group BD, and no patients in group B developed bradycardia ( P < 0.05). Conclusion: The addition of dexmedetomidine 100 μg to bupivacaine 0.5% during ultrasound-guided combined femoral and sciatic block for below knee surgery was associated with a prolonged duration of analgesia. However, this may be associated with significant bradycardia requiring treatment.
机译：背景与目的：神经鞘内注射右美托咪定（一种α2-肾上腺素受体激动剂）可延长镇痛的持续时间。我们假设在膝关节以下手术后向布比卡因中添加右美托咪定会延长术后镇痛作用。材料和方法：经伦理学批准，将60例计划在股骨坐骨神经联合下进行膝下手术的患者随机分为两组，分别使用0.5％布比卡因（B组）或0.5％布比卡因联合100μg进行阻滞布比卡因-右美托咪定（BD组）。运动和感觉阻滞发作时间;记录封锁和镇痛的持续时间。结果：BD组的感觉和运动阻滞发作时间比B组缩短了20％（P <0.01）。 BD组的感觉和运动阻滞持续时间长于B组（分别为+ 45％和+40％）（P <0.01）。 BD组的镇痛持续时间比B组长75％（P <0.01）。 BD组的收缩压，舒张动脉血压水平和心率显着降低，BD组为6例，B组无心动过缓（P <0.05）。结论：在超声引导下的股骨和坐骨神经阻滞联合膝关节以下手术期间，向0.5％布比卡因中添加100μg右美托咪定可延长镇痛时间。但是，这可能与需要治疗的严重心动过缓有关。

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