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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effects of Perineural Administration of Dexmedetomidine in Combination with Levobupivacaine in a Rat Sciatic Nerve Block
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Effects of Perineural Administration of Dexmedetomidine in Combination with Levobupivacaine in a Rat Sciatic Nerve Block

机译：右美托咪定与左旋布比卡因联合神经营养对大鼠坐骨神经阻滞的影响

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Objective: The aim of this study was to assess if perineural administration of dexmedetomidine combined with levobupivacaine increases the duration of the sensory and motor blockade of a sciatic peripheral nerve block in rats.Methods: Forty male Sprague-Dawley rats were randomly divided into 5 experimental groups: Group 1, sham; Group 2, perineural levobupivacaine (0.2 mL of a 0.5% solution) and subcutaneous saline; Group 3, perineural levobupivacaine (0.2 mL of a 0.5% solution) plus dexmedetomidine (20 ug/kg dexmedetomidine) and subcutaneous saline; Group 4, perineural saline and subcutaneous dexmedetomidine; and Group 5, perineural saline and subcutaneous saline. Pain reflexes in response to a thermal stimulus were measured at 0 and 240 minutes after drug administration by using a hot-plate and tail-flick tests. Neurobehavioral status, including sensory and motor functions, was assessed by an investigator who was blinded to the experimental groups every 30 minutes until normal functioning resumed. Results: The sensory and motor blockades of the rats did not increase in the treatment with dexmedetomidine plus levobupivacaine when compared with the treatment with levobupivacaine alone at all the time points (P > 0.05). Compared with rats in Group 2, those in Group 3 showed significantly higher latency times at 30 and 60 minutes in the hot plate test (P < 0.01). At 30 and 60 minutes, the latency times of the rats in Group 3 were longer than those in Group 2 in the tail-flick test (P < 0.01). Furthermore, the durations of the complete sensory and motor blockade were similar when treatment with levobupivacaine plus dexmedetomidine was compared with treatment with levobupivacaine alone. Conclusions: A 20ug/kg dose of dexmedetomidine added to levobupivacaine did not increase the duration of the sensory and motor blockades in rats. However, treatment with dexmedetomidine plus levobupivacaine increased the quality of analgesia in rats.
机译：目的：本研究旨在评估右美托咪定联合左旋布比卡因的神经内给药是否可增加大鼠坐骨神经末梢神经阻滞的感觉和运动阻滞时间。方法：将40只雄性Sprague-Dawley大鼠随机分为5只实验动物组：第一组，假;第2组，神经周围左旋布比卡因（0.2 mL 0.5％溶液）和皮下生理盐水;第3组，神经周围左旋布比卡因（0.2 mL 0.5％溶液）加右美托咪定（20 ug / kg右美托咪定）和皮下盐水;第4组，神经周围盐水和皮下右美托咪定;第5组，神经周围盐水和皮下盐水。在给药后0和240分钟通过热板和甩尾试验测量对热刺激的疼痛反射。由研究者评估神经行为状态，包括感觉和运动功能，该研究者每30分钟对实验组视而不见，直至恢复正常功能。结果：与单独使用左旋布比卡因治疗相比，右美托咪定加左旋布比卡因治疗的大鼠在感觉和运动阻滞方面均未增加（P> 0.05）。与第2组的大鼠相比，第3组的大鼠在热板测试中显示30和60分钟时的潜伏时间明显更长（P <0.01）。在甩尾试验中，在第30和60分钟时，第3组大鼠的潜伏期比第2组中的潜伏期长（P <0.01）。此外，将左旋布比卡因加右美托咪定与单纯左旋布比卡因治疗相比，完全感觉和运动阻滞的持续时间相似。结论：左旋布比卡因中添加20ug / kg剂量的右美托咪定不会增加大鼠的感觉和运动阻滞持续时间。但是，右美托咪定加左旋布比卡因的治疗可提高大鼠的镇痛效果。

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