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首页> 外文期刊>Science World Journal >Haematological, Pathological And Plasma Biochemical Changes In Rabbits Experimentally Infected With Trypanosoma congolense
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Haematological, Pathological And Plasma Biochemical Changes In Rabbits Experimentally Infected With Trypanosoma congolense

机译：实验性感染锥虫锥虫的血液学，病理学和血浆生化变化

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Chinchilla x New Zealand white cross breed rabbits (N=24) were challenged with strain of T. congolense. The infections were characterized by intermittent pyrexia, undulating parasitaemia, anorexia and emaciation. The major haematological changes observed were anaemia that was macrocytic normochromic at the first week of the infection and later became normochromic normocytic till the end of the experiment and leucopaenia that is characterized by neutropaenia, eosinopaenia and lymphocytosis. Plasma biochemical changes include hypoglycaemia, elevated total protein and plasma cholesterol. There were significant (p0.05) elevation of Alkaline phospatase (ALP), Aspertate aminotransferase (AST), total bilirubin and fluctuating changes in the levels of plasma Alanine aminotransferase (ALT) and urea. Gross pathological changes include congested and oedematous lungs, mucoid enteritis, hepatomegaly and splenomegaly. Histopathological changes include mild congestion of the splenic pulp, mild venous congestion of the liver, pulmonary congestion, acute bronchopneumonia, severe emphysema of the lung, and focal centrilobular necrosis and periportal mononuclear cell aggregation in the kidney. This study shed light on the dynamics of haematological alteration and distortion of architectural frame work of various tissues of rabbits experimentally infected with T. congolense and suggested that rabbit is susceptible to T. congolense and could act as reservoir for trypanosomosis of ruminants and domesticated dogs used for hunting.
机译：用浓密T. congolense菌株攻击Chinchilla x新西兰白杂交种兔（N = 24）。感染的特征是间歇性发热，波动性寄生虫血症，厌食和消瘦。观察到的主要血液学变化是贫血，它在感染的第一周为大细胞性常血性贫血，后来变成正色性常血性贫血，直到实验结束，以及以中性粒细胞减少，嗜酸性粒细胞减少和淋巴细胞增多为特征的白斑。血浆生化变化包括低血糖症，总蛋白升高和血浆胆固醇。碱性磷酸酶（ALP），天冬氨酸氨基转移酶（AST），总胆红素和血浆丙氨酸氨基转移酶（ALT）和尿素水平的波动显着（p <0.05）升高。总体病理变化包括肺充血和水肿，粘液性肠炎，肝肿大和脾肿大。组织病理学变化包括脾髓轻度充血，肝轻度静脉充血，肺充血，急性支气管肺炎，严重的肺气肿，局灶性小叶坏死和肾门静脉单核细胞聚集。这项研究揭示了实验感染了锥虫的家兔各种组织的血液学变化和建筑构架变形的动力学，并暗示了兔很容易感染锥虫，并且可以作为反刍动物和家养犬锥虫病的贮藏库。狩猎。

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