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首页> 外文期刊>Science Research >Toxicologic and hygienic characteristics of p-373-2-20; p-5003-ac;p-294-2-35 polyols and prognosis of their potential danger for environment
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Toxicologic and hygienic characteristics of p-373-2-20; p-5003-ac;p-294-2-35 polyols and prognosis of their potential danger for environment

机译：p-373-2-20的毒理学和卫生特性; p-5003-ac; p-294-2-35多元醇及其对环境潜在危险的预后

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Studied the toxic effects polyoxipropylenpolyols in acute and subacute experiments on warm-blooded animals. It is established that they are pertained to the IV hazard class; have polytropic general toxic effect; on the level of toxic doses they influence on the generative function and the genetic apparatus; inhibit and disrupt the interaction between the cellular and humoral immunity. Experiments were performed on adult Wistar white rats, white mouses, guinea pigs, hybrid mouse lines BALB / C, (SBAc57BL) F1, CBA / Lac, and rabbits of the chinchilla race [4-6]. The objects of the investigation were polyoxipropylenthriols with molecular masses 5000M (P-5003-AC), and 370M (P-373-2-20), and polyoxipropylated amine with molecular mass 290M (P-294-2-35). Polyoxipropylenpolyols P-5003-AC, P-373-2-20 and P-294-2-35 in doses of 1/10 and 1/100 DL50 have a toxic effect on the generatic function and the genetic apparatus, and in doses 1/10, 1/100 and 1/1000 DL50 inhibit and disrupt the cooperative interaction of cellular and humoral immunity. In all cases, the dose of 1/10000 DL50 was inoperative, it is equal to 3.23; 3.62 and 1.48 mg / kg of animal weight, respectively, for P-373-2-20, P-5003-AC and P-294-2-35.
机译：研究了聚氧丙烯丙基多元醇在急性和亚急性实验中对温血动物的毒性作用。确定它们属于IV级危险等级;具有多方性的一般毒性作用;在毒性剂量水平上，它们影响生殖功能和遗传设备;抑制和破坏细胞和体液免疫之间的相互作用。实验是在成年Wistar白色大鼠，白色小鼠，豚鼠，杂交小鼠品系BALB / C，（SBAc57BL）F1，CBA / Lac和黄鼠族兔中进行的[4-6]。研究的对象是分子量为5000M（P-5003-AC）和370M（P-373-2-20）的聚氧丙基丙醇和分子量为290M（P-294-2-35）的聚氧丙基丙胺。剂量为1/10和1/100 DL50的聚氧丙烯丙基多元醇P-5003-AC，P-373-2-20和P-294-2-35对生殖功能和遗传装置有毒性作用，剂量为1 / 10、1 / 100和1/1000 DL50抑制并破坏细胞和体液免疫的协同相互作用。在所有情况下，无效的1/10000 DL50剂量等于3.23; P-373-2-20，P-5003-AC和P-294-2-35的动物重分别为3.62和1.48 mg / kg。

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