...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Open Pharmaceutical Sciences Journal >Tissue-specific Effect of Coenzyme Q10 Supplementation on the Oxidative Post-translational Modifications in the Rat
【24h】

Tissue-specific Effect of Coenzyme Q10 Supplementation on the Oxidative Post-translational Modifications in the Rat

机译：补充辅酶Q10对大鼠氧化后翻译修饰的组织特异性作用

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background:Coenzyme Q (CoQ), a component of almost all cellular membranes, has been postulated to act as an antioxidant due to its capacity to recycle the oxidized alpha-tocopherol and scavenge peroxy radicals.Objective:The present study was performed to investigate the in vivo effects of a long-term supplementation of CoQ_(10) on oxidative protein modifications in some tissues as the plasma and the brain of the Sprague Dawley rat.Method:Male Sprague Dawley rats of 14 months age were supplemented with 150 mg/kg/d of CoQ_(10) and the effects on oxidative post-translational modifications analyzed after 13 weeks of supplementation.Results:Supplementation of CoQ_(10) for thirteen weeks in adult animals resulted in decreased protein carbonyls due to oxidative post-translational modifications in the plasma (approximately 21%) but an increase of the same in the brain tissue homogenate (approximately 21%) was observed. These alterations were statistically significant in the former while the increase in the latter was statistically not significant.Conclusion:The results suggest a tissue-specific effect of dietary supplementation of CoQ_(10) on oxidative post-translational modifications by carbonylation in the rats.
机译：背景：辅酶Q（CoQ）是几乎所有细胞膜的组成部分，由于其能够循环利用氧化的α-生育酚和清除过氧自由基而被假定为抗氧化剂。长期补充CoQ_（10）对Sprague Dawley大鼠血浆和脑部某些组织中氧化蛋白修饰的体内作用。方法：补充14个月大的雄性Sprague Dawley大鼠150补充13周后，分析了CoQ_（10）的mg / kg / d以及对氧化后翻译修饰的影响。结果：成年动物补充CoQ_（10）十三周导致氧化后的蛋白质羰基减少在血浆中进行翻译修饰（约21％），但在脑组织匀浆中观察到翻译修饰的增加（约21％）。这些改变在前者中具有统计学意义，而后者的增加在统计学上不显着。结论：结果表明膳食补充辅酶Q_（10）对大鼠羰基化氧化后翻译修饰具有组织特异性作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号