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首页> 外文期刊>Open Pharmaceutical Sciences Journal >Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique
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Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique

机译：溶剂蒸发技术研究微球和纳米球配方中不同因素的影响

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摘要

Background:There are various methods of formulation of micro and nanospheres such as solvent evaporation, solvent removal, polymerization, hot-melt encapsulation, coacervation, phase/wet inversion, spray drying, spray congealing etc . Amongst these all, solvent evaporation is one of the most widely used, researched, easy, accessible methods and for which many patents have been applied. It is thus imperative to understand the basics of effect of formulation variables and design of solvent evaporation method which will be covered in this review article.Objective:To discuss the various formulation factors while designing the robust micro and nanospherical systems with better morphology, entrapment and release of the drugs.Method:Systematic analysis of the relevant literature, bibliographies, and interactions with investigators.Results:From the investigation of different literatures, it was found that various factors of solvent evaporation technique may be controlled in order to design the micro and nanospheres of suitable morphology, entrapment and release characters.Conclusion:Various factors like type of polymer used, weight, viscosity, hydrophilicity, concentration, polymer ratio, stirring speed, emulsifier concentration, concentration of cross-linking agents, type of solvent used, rate of addition of solvent etc . Affect the yield, morphology, release and entrapment of the drug inside the system. Hence, these factors play crucial role in the design of a robust micro and nanospherical system.
机译：背景：微球和纳米球的配制方法多种多样，例如溶剂蒸发，溶剂去除，聚合，热熔包封，凝聚，相/湿转化，喷雾干燥，喷雾凝结等。在所有这些之中，溶剂蒸发是最广泛使用，研究，简便，可访问的方法之一，并且已申请了许多专利。因此，有必要了解本文将涉及的配方变量的影响和溶剂蒸发方法的设计的基本知识。目的：在设计具有更好形态学，截留性能和稳定性的稳健的微米和纳米球形系统的同时，讨论各种配方因素。方法：对相关文献，参考书目以及与研究者的相互作用进行系统分析。结果：从不同文献的研究中发现，可以控制溶剂蒸发技术的各种因素，以设计微量和化学成分。结论：各种因素，例如所用聚合物的类型，重量，粘度，亲水性，浓度，聚合物比，搅拌速度，乳化剂浓度，交联剂的浓度，所用溶剂的类型，速率溶剂等的添加。影响系统内部药物的产量，形态，释放和截留。因此，这些因素在设计稳健的微米和纳米球形系统中起着至关重要的作用。

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