...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Open Pharmaceutical Sciences Journal >Antifungal Activities and Characterization of Some New Environmentally Safe Cu (II) Surfactants Substituted 2-Amino-6-Methyl Benzothiazole
【24h】

Antifungal Activities and Characterization of Some New Environmentally Safe Cu (II) Surfactants Substituted 2-Amino-6-Methyl Benzothiazole

机译：替代2-氨基-6-甲基苯并噻唑的一些新型环保铜（II）表面活性剂的抗真菌活性和表征

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background:Biologically potent compounds are one of the most important classes of materials for the upcoming generations.Objectives:Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. Methods:The copper surfactants substituted 2-amino-6-methyl benzothiazole were synthesized. The synthesized complexes have been characterized by IR, NMR, ESR spectroscopic methods. The antifungal activities have been evaluated by testing against Alternaria alternate fungi. All complexes showed good antifungal activity because chelation increases the anti-microbial potency. Result:The studies suggest that the copper (II) ions in soaps may be responsible for the enhancement of the activity against fungi. The evaluation of anti -fungal studies further revealed that fungitoxicity of the complexes also depends on the nature of metal ions. The chelation reduces the polarity of central metal ion mainly because of partial attaining of its positive charge with the donor groups and possible π- electron delocalization over the whole chelate ring. Such chelation increases the lipophilic character of the central atom, which subsequently favors its permeation through the lipoid layer of the cell membrane. Their efficiency increases with their concentration.
机译：背景：具有生物活性的化合物是后代最重要的材料类别之一。目的：越来越多的微生物传染病和耐药性病原体对开发新颖，有效，安全和改良的多种抗菌剂产生了需求和紧迫性。方法：合成了取代2-氨基-6-甲基苯并噻唑的铜表面活性剂。合成的配合物已通过IR，NMR，ESR光谱法表征。通过针对 Alternaria替代真菌进行测试，评估了其抗真菌活性。所有的复合物都显示出良好的抗真菌活性，因为螯合增加了抗微生物效力。结果：研究表明，肥皂中的铜（II）离子可能是增强抗真菌活性的原因。对抗真菌研究的评估进一步表明，该配合物的真菌毒性还取决于金属离子的性质。螯合作用降低了中心金属离子的极性，这主要是由于部分金属与供体基团获得了正电荷以及整个螯合环上可能存在π电子离域。这种螯合增加了中心原子的亲脂性，其随后有利于其渗透通过细胞膜的脂质层。他们的效率随着他们的专注而增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号