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首页> 外文期刊>Sinusitis >State-of-the-Art Adult Chronic Rhinosinusitis Microbiome: Perspective for Future Studies in Pediatrics
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State-of-the-Art Adult Chronic Rhinosinusitis Microbiome: Perspective for Future Studies in Pediatrics

机译：最新的成人慢性鼻-鼻窦炎微生物组：儿科未来研究的前景

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Chronic rhinosinusitis (CRS) is a prevalent disease that causes persistent mucosal inflammation and is associated with bacterial infection, which is thought to play a role in the inflammatory process. Microbiome analysis provides insight to host–microbial interactions. Disturbances in the host and commensal bacteria interaction may lead to CRS. Culture-based methods are useful to isolate some microorganisms but are unable to grow a majority of the bacteria. A review of the literature shows that several recent studies attempted to overcome this issue by using molecular techniques, such as microbial RNA sequencing, to describe the CRS microbiome. All of these studies were performed in adults, with no comparative studies reported in the pediatric population. Similar studies, utilizing molecular techniques, are needed to better understand the mechanism of CRS in children. Because valuable data from these adult studies may help to bridge the gap in our knowledge of the microbiome in pediatric CRS, we present an overview of the methodology and results behind the current microbiomic approach to adult CRS to set the stage for its use in the study of CRS in children.
机译：慢性鼻-鼻窦炎（CRS）是一种普遍的疾病，会引起持续的粘膜炎症并与细菌感染有关，细菌感染被认为在炎症过程中起作用。微生物组分析为宿主与微生物之间的相互作用提供了见识。宿主和共生细菌相互作用的紊乱可能导致CRS。基于培养的方法可用于分离某些微生物，但不能使大多数细菌生长。文献综述显示，最近的一些研究试图通过使用分子技术（例如微生物RNA测序）来描述CRS微生物组来克服这一问题。所有这些研究都是在成人中进行的，而在儿科人群中没有比较研究的报道。需要利用分子技术进行类似的研究，以更好地了解儿童CRS的机制。由于来自这些成人研究的宝贵数据可能有助于弥合我们在儿科CRS中微生物组知识的差距，因此，我们对当前成人CRS的微生物学方法背后的方法学和结果进行了概述，从而为其在研究中的应用奠定了基础儿童的CRS。

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