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首页> 外文期刊>Open Journal of Modern Neurosurgery >Can High Dose Metamizol Medication Contribute to Postsurgical Hemorrhage:A Case Report
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Can High Dose Metamizol Medication Contribute to Postsurgical Hemorrhage:A Case Report

机译：大剂量美他唑药物能否促进术后出血：一例报告

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摘要

The use of metamizol significantly increased in the last decade, especially in non US countries [1]. Although metamizol is known to be a non selective COX inhibitor and therefore has platelet inhibiting potential, it is widely used in pain management in postsurgical setting. Methods: We present a case of bleeding after microsurgical decompression of a narrow lumbar spinal canal. Our patient developed a bleeding complication 3 days after the surgery. The bleeding spontaneously resolved after stopping the application of metamizol. Metamizol is a non selective COX inhibitor and is used as standard analgetic drug after surgery in our department, whereas other COX inhibitors are not. We made an intensive literature research to evaluate the prohaemorrhagic potential of metamizol. Metamizol has proven dose dependent platelet inhibiting effect. Conclusions: This is a quite ordinary case and there is no proof of metamizol being responsible for the bleeding in this case, it still poses questions at our daily routine and the question about a dose dependent clinically relevant prohaemorrhagic effect of metamizol remains unanswered. A proper study is needed.
机译：在过去的十年中，特别是在非美国国家，美他唑的使用量显着增加[1]。尽管已知美他唑是一种非选择性的COX抑制剂，因此具有抑制血小板的潜力，但它广泛用于术后环境的疼痛控制中。方法：我们提出了一例狭窄腰椎管显微手术减压后出血的案例。我们的病人在手术后3天出现了出血并发症。停止使用美他唑后，出血会自发解决。美他唑是一种非选择性的COX抑制剂，在我科手术后被用作标准的止痛药，而其他COX抑制剂则不是。我们进行了深入的文献研究，以评估美他唑的止血潜力。美他唑已被证明具有剂量依赖性的血小板抑制作用。结论：这是一个非常普通的案例，在这种情况下没有证据证明美他唑是导致出血的原因，它仍然在我们的日常工作中提出了疑问，关于美他唑的剂量依赖性临床相关的止血效果的问题仍未得到解答。需要进行适当的研究。

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