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首页> 外文期刊>Sokoto Journal of Veterinary Sciences >Diminazene aceturate residues in tissues of dogs treated with secnidazole-diminazene aceturate combination and with diminazene aceturate alone
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Diminazene aceturate residues in tissues of dogs treated with secnidazole-diminazene aceturate combination and with diminazene aceturate alone

机译：替硝唑-醋酸二咪唑和单独使用醋酸二咪唑处理的犬组织中醋酸二咪唑残留

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摘要

Dimninazene aceturate concentration in plasma and residues in tissues of dogs treated with secnidazole-diminazene aceturate combination and with diminazene aceturate alone was investigated in apparently healthy dogs. Fourteen apparently healthy dogs were randomly assigned to 3 groups. The first group consisted of 6 dogs pre-treated with 100 mg/kg secnidazole (SEC) orally 30 min before administration of 3.5 mg/kg diminazene aceturate (DA) im. The second group consisted of 6 dogs treated with 3.5 mg/kg DA im alone, while the third group had 2 dogs untreated and used to prepare the control tissues and standards. Blood samples were collected at 24, 48 and 72 h post-administration of DA and serum harvested for estimation of DA concentrations in the serum. For estimation of DA residues in tissues, 2 dogs were sacrificed in each group at 240, 360 and 480 h post-administration of the drugs. Ten grams of tissue samples (liver, kidney, brain, heart and skeletal muscle) were collected in triplicate. Intramuscular administration of DA, led to detectable and measurable levels of DA up to 72 h in the serum of both groups of dogs. However, there was no significant difference in the serum concentration of DA in both groups of dogs from 24 – 72 h. The concentration of DA was significantly (p < 0.05) higher in the brain of SEC pre-treated dogs at 240 h. In the kidney and liver, DA concentration was significantly (p < 0.05) higher in SEC pre-treated dogs at 480 h. There was no significant difference in the DA concentration in the myocardium and skeletal muscles of both groups of dogs. We therefore concluded that DA persists in the tissues of treated dogs beyond 20 days post-treatment and that SEC alters the elimination pattern of DA in SEC pre-treated dogs.
机译：在表面健康的狗中，研究了用塞克硝唑-二米氮烯醋酸盐组合物和单独使用二米氮烯醋酸盐治疗的狗的血浆中地亚米那嗪乙酸盐的浓度和组织中的残留物。将十四只看似健康的狗随机分为3组。第一组包括6只狗，在给予3.5 mg / kg醋酸二咪唑（im）之前30分钟，口服100 mg / kg的塞克硝唑（SEC）进行预处理。第二组由6只单独接受3.5 mg / kg DA im治疗的狗组成，而第三组则有2只未经治疗的狗，用于制备对照组织和标准品。在DA施用后24、48和72小时收集血样，并收集血清以估计血清中的DA浓度。为了估计组织中的DA残留，在给药后240、360和480小时，每组杀死2只狗。一式三份收集十克组织样品（肝，肾，脑，心脏和骨骼肌）。肌内施用DA导致两组狗的血清中长达72小时的可检测和可测量的DA水平。但是，两组狗在24 – 72 h内的DA血清浓度无显着差异。在240小时时，SEC预处理犬的大脑中DA的浓度显着较高（p <0.05）。在肾脏和肝脏中，在480 h SEC预处理的狗中，DA浓度显着较高（p <0.05）。两组狗的心肌和骨骼肌中DA浓度没有显着差异。因此，我们得出结论，在治疗后20天以上，DA在治疗犬的组织中持续存在，并且SEC改变了SEC预处理犬中DA的消除模式。

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