...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>South African medical journal = >Antibiotic prescription practices and their relationship to outcome in South African intensive care units: findings of the prevalence of infection in South African Intensive Care Units (PISA) study
【24h】

Antibiotic prescription practices and their relationship to outcome in South African intensive care units: findings of the prevalence of infection in South African Intensive Care Units (PISA) study

机译：南非重症监护病房的抗生素处方实践及其与预后的关系：南非重症监护病房（PISA）研究的感染率调查结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND. The emergence of multidrug-resistant, extensively resistant and pan-resistant pathogens and the widespread inappropriate use of antibiotics is a global catastrophe receiving increasing attention by health care authorities. The antibiotic prescription practices in public and private intensive care units (ICUs) in South Africa are unknown. OBJECTIVE. To document antibiotic prescription practices in public and private ICUs in South Africa and to determine their relationship to patient outcomes. METHODS. A national database of public and private ICUs in South Africa was prospectively studied using a proportional probability sampling technique. RESULTS. Two hundred and forty-eight patients were recruited. Therapeutic antibiotics were initiated in 182 (73.5%), and 54.9% received an inappropriate antibiotic initially. De-escalation was practised in 33.3% and 19.7% of the public and private sector patients, respectively. Antibiotic duration was inappropriate in most cases. An appropriate choice of antibiotic was associated with an 11% mortality, while an inappropriate choice was associated with a 27% mortality (p=0.01). The mortality associated with appropriate or inappropriate duration of antibiotics was 17.6% and 20.6%, respectively (p=0.42). CONCLUSION. Inappropriate antibiotic prescription practices in ICUs in the public and private sectors in South Africa are common and are also associated with poor patient outcomes.
机译：背景。多药耐药，广谱耐药和泛耐药病原体的出现以及抗生素的不适当广泛使用是全球性的灾难，受到医疗机构的越来越多的关注。南非公立和私立重症监护病房（ICU）的抗生素处方做法尚不明确。目的。记录南非公共和私人ICU中的抗生素处方做法，并确定其与患者预后的关系。方法。使用比例概率抽样技术对南非的公共和私人ICU的国家数据库进行了前瞻性研究。结果。招募了248位患者。 182种（73.5％）开始使用治疗性抗生素，最初有54.9％的患者使用了不合适的抗生素。公立和私立医院的患者分别进行了降级治疗，分别占33.3％和19.7％。在大多数情况下，抗生素持续时间不合适。的抗生素的适当选择，用11％的死亡率相关，而不合适的选择用27％的死亡率（p值= 0.01）相关联。与适当或不适当的抗生素疗程相关的死亡率分别为17.6％和20.6％（p = 0.42）。结论。南非的公共部门和私营部门的重症监护病房中不适当的抗生素处方做法很普遍，而且还与患者预后不良有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号