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首页> 外文期刊>South East Asia Journal of Public Health >Influence of ethnicity on glycated hemoglobin (HbA1c): A cross-sectional study among newly diagnosed type 2 diabetic Arab Population
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Influence of ethnicity on glycated hemoglobin (HbA1c): A cross-sectional study among newly diagnosed type 2 diabetic Arab Population

机译：种族对糖化血红蛋白（HbA1c）的影响：一项新诊断为2型糖尿病阿拉伯人群的横断面研究

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Diabetes is a global health burden and threat that needs proper managements. Glycosylated hemoglobin (HbA1c) is an important marker, both in the diagnosis and treatment of diabetes. The purpose of the study was to demonstrate the influence of ethnicity on HbA1c in relation to fasting plasma glucose (FPG), by observation among newly diagnosed type 2 diabetics in Arab population, with a view to speculate comparison with other population groups in order to make a more rationale management plan of diabetes for different ethnic groups. This cross sectional study was performed amongst 573 newly diagnosed, untreated type 2 diabetic subjects attending the outpatient department (OPD) of Al-Qunfudah General Hospital Diabetic centre, in the Kingdom of Saudi Arabia (KSA) from June 2010 to April 2013. Data were collect by face to face interview using pre-tested questionnaire. Height, weight, body mass index (BMI), blood-pressure, fasting and post-prandial venous plasma glucose, HbA1c and serum creatinine were measured. Patients receiving any treatment for diabetes, suffering from Type 1 Diabetes Mellitus (T1DM), having ketonuria ≥2+, pregnant and patients of hemolytic anemia were excluded from the study. Sensitivity, specificity and the area under the Receiver Operating Characteristic (ROC) Curve for HbA1c using different cut-off values were calculated using venous FPG considering gold standard. The analysis was done by computer using SPSS version 22.0. Mean fasting plasma glucose was 227.9±81.45mg/dl and mean HbA1c was 9.79±2.22%, 269 patients (47%) had HbA1c >10%, much above ≥6.5%, cutoff determined by American Diabetic association (ADA). For diagnosing diabetes, the optional cut-off for HbA1c was 7.9%, with sensitivity of 83.6%, specificity of 87.8%, positive predictive value of 98.6%, and negative predictive value of 33.3%. These characterizations would not only accord to construct more tactical initiative for comparison but also instigate the rationale to individualize HbA1c on ethnic basis for diabetes management protocols.South East Asia Journal of Public Health Vol.6(2) 2016: 42-47
机译：糖尿病是全球性的健康负担和威胁，需要适当的管理。糖基化血红蛋白（HbA1c）在糖尿病的诊断和治疗中都是重要的标志物。该研究的目的是通过观察阿拉伯人群中新诊断出的2型糖尿病患者中的空腹血糖（FPG），来证明种族对HbA1c的影响，以推测与其他人群的比较，从而得出结论。针对不同种族的更合理的糖尿病管理计划。该横断面研究于2010年6月至2013年4月在沙特阿拉伯王国（KSA）Al-Qunfudah综合医院糖尿病中心门诊（OPD）的573名新诊断，未经治疗的2型糖尿病受试者中进行。使用预先测试的问卷进行面对面采访。测量身高，体重，体重指数（BMI），血压，禁食和餐后静脉血浆葡萄糖，HbA1c和血清肌酐。该研究排除了接受任何糖尿病治疗，患有1型糖尿病（T1DM），酮尿症≥2+的孕妇，孕妇和溶血性贫血患者。使用考虑了金标准的静脉FPG，使用不同的截断值计算HbA1c的敏感性，特异性和受体工作特征（ROC）曲线下的面积。使用SPSS 22.0版通过计算机进行分析。平均空腹血糖为227.9±81.45mg / dl，平均HbA1c为9.79±2.22％，269例患者（47％）的HbA1c> 10％，远高于6.5％，由美国糖尿病协会（ADA）确定。对于糖尿病的诊断，HbA1c的选择性截止值为7.9％，敏感性为83.6％，特异性为87.8％，阳性预测值为98.6％，阴性预测值为33.3％。这些特征不仅有助于构建更多的战术倡议进行比较，而且可以激发根据种族基础针对糖尿病管理协议个性化HbA1c的理由。东南亚公共卫生杂志Vol.6（2）2016：42-47

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