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首页> 外文期刊>Standards in Genomic Sciences >Complete genome sequence of new bacteriophage phiE142, which causes simultaneously lysis of multidrug-resistant Escherichia coli O157:H7 and Salmonella enterica
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Complete genome sequence of new bacteriophage phiE142, which causes simultaneously lysis of multidrug-resistant Escherichia coli O157:H7 and Salmonella enterica

机译：新噬菌体phiE142的完整基因组序列，可同时裂解耐多药的大肠杆菌O157：H7和肠炎沙门氏菌

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摘要

The emergence of antibiotic-resistant foodborne bacteria is a global health problem that requires immediate attention. Bacteriophages are a promising biotechnological alternative approach against bacterial pathogens. However, a detailed analysis of phage genomes is essential to assess the safety of the phages prior to their use as biocontrol agents. Therefore, here we report the complete genome sequence of bacteriophage phiE142, which is able to lyse Salmonella and multidrug-resistant Escherichia coli O157:H7 strains. Bacteriophage phiE142 belongs to the Myoviridae family due to the presence of long non-flexible tail and icosahedral head. The genome is composed of 121,442 bp and contains 194 ORFs, and 2 tRNAs. Furthermore, the phiE142 genome does not contain any genes coding for food-borne allergens, antibiotics resistance, virulence factors, or associated with lysogenic conversion. The bacteriophage phiE142 is characterized by broad host range and compelling genetic attributes making them potential candidates as a biocontrol agent.
机译：耐药性食源性细菌的出现是一个全球性的健康问题，需要立即引起注意。噬菌体是一种针对细菌病原体的有前途的生物技术替代方法。但是，对噬菌体基因组进行详细分析对于在将其用作生物防治剂之前评估其安全性至关重要。因此，在这里我们报告了噬菌体phiE142的完整基因组序列，它能够裂解沙门氏菌和耐多药性的大肠杆菌O157：H7菌株。噬菌体phiE142由于存在长长的非柔性尾巴和二十面体头部而属于Myoviridae家族。基因组由121,442 bp组成，包含194个ORF和2个tRNA。此外，phiE142基因组不包含任何编码食源性过敏原，抗生素抗性，毒力因子或与溶源性转化相关的基因。噬菌体phiE142具有广泛的宿主范围和引人注目的遗传特性，使其成为生物防治剂的潜在候选者。

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