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首页> 外文期刊>Revista chilena de radiologia >Imágenes del depósito de gadolinio en el sistema nervioso central
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Imágenes del depósito de gadolinio en el sistema nervioso central

机译：central在中枢神经系统沉积的影像

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摘要

Magnetic resonance imaging has been shown to be very useful in the diagnosis and monitoring of multiple diseasesaffecting the central nervous system. Gadolinium has been used extensively worldwide. It has been estimated thatsince its introduction more than two hundred million doses of GBCA have been administered globally.Gadolinium-based contrast agents (GBCAs) were long considered medicines with a high safety profle, the literature reports incidences of immediate adverse effects such as headache, dizziness, and altered sense of taste.Studies performed a few years after the introduction of GBCA showed that there were gadolinium deposits in thetissues but their clinical signifcance was not known. It wasn’t until 2006 when the frst reports were published thatassociated the gadolinium ion tissue deposits from GBCA with a systemic in?ammatory entity of the connectivetissue similar to scleroderma known as Nephrogenic Systemic Fibrosis (NSF), in patients with chronic renal failure.In 2013, the association between the use of GBCAs and the progressive increase in the signal intensity of thedentate nucleus and the globus pallidus in T1-weighted MRI images without contrast medium, was described forthe frst time.This review describes the most relevant aspects of the pathophysiology of these fndings taking into account theirdifferential diagnosis.
机译：磁共振成像已被证明在诊断和监测影响中枢神经系统的多种疾病中非常有用。 worldwide已在世界范围内广泛使用。据估计，自从全球范围内已引入超过2亿剂的GBCA。基于ado的造影剂（GBCA）长期以来被认为是具有高安全性的药物，文献报道了诸如头痛，引入GBCA几年后进行的研究表明，组织中存在g沉积物，但其临床意义尚不清楚。直到2006年才发表第一份报告，将患有慢性肾功能衰竭患者的GBCA ion离子组织沉积物与结缔组织的全身炎症性炎症相联系，类似于硬皮病称为肾原性系统性纤维化（NSF）。 2013年，首次描述了在没有造影剂的T1加权MRI图像中，GBCA的使用与齿状核和苍白球信号强度的逐渐增加之间的关系，该综述描述了病理生理学的最相关方面这些发现考虑到了它们的鉴别诊断。

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