...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Standards in Genomic Sciences >Chromosomal features of Escherichia coli serotype O2:K2, an avian pathogenic E. coli
【24h】

Chromosomal features of Escherichia coli serotype O2:K2, an avian pathogenic E. coli

机译：禽病原性大肠杆菌O2：K2血清型的染色体特征

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Escherichia coli causing infection outside the gastrointestinal system are referred to as extra-intestinal pathogenic E. coli. Avian pathogenic E. coli is a subgroup of extra-intestinal pathogenic E. coli and infections due to avian pathogenic E. coli have major impact on poultry production economy and welfare worldwide. An almost defining characteristic of avian pathogenic E. coli is the carriage of plasmids, which may encode virulence factors and antibiotic resistance determinates. For the same reason, plasmids of avian pathogenic E. coli have been intensively studied. However, genes encoded by the chromosome may also be important for disease manifestation and antimicrobial resistance. For the E. coli strain APEC_O2 the plasmids have been sequenced and analyzed in several studies, and E. coli APEC_O2 may therefore serve as a reference strain in future studies. Here we describe the chromosomal features of E. coli APEC_O2. E. coli APEC_O2 is a sequence type ST135, has a chromosome of 4,908,820?bp (plasmid removed), comprising 4672 protein-coding genes, 110 RNA genes, and 156 pseudogenes, with an average G?+?C content of 50.69%. We identified 82 insertion sequences as well as 4672 protein coding sequences, 12 predicated genomic islands, three prophage-related sequences, and two clustered regularly interspaced short palindromic repeats regions on the chromosome, suggesting the possible occurrence of horizontal gene transfer in this strain. The wildtype strain of E. coli APEC_O2 is resistant towards multiple antimicrobials, however, no (complete) antibiotic resistance genes were present on the chromosome, but a number of genes associated with extra-intestinal disease were identified. Together, the information provided here on E. coli APEC_O2 will assist in future studies of avian pathogenic E. coli strains, in particular regarding strain of E. coli APEC_O2, and aid in the general understanding of the pathogenesis of avian pathogenic E. coli .
机译：在肠胃系统外引起感染的大肠杆菌被称为肠外致病性大肠杆菌。禽病原性大肠杆菌是肠外病原性大肠杆菌的一个子类，禽类病原性大肠杆菌引起的感染对全世界的家禽生产经济和福利产生重大影响。禽病原性大肠杆菌的一个几乎定义的特征是质粒的运输，该质粒可以编码毒力因子和决定抗生素的抗性。由于相同的原因，已经深入研究了禽病原性大肠杆菌的质粒。但是，由染色体编码的基因对于疾病表现和抗菌素耐药性也可能很重要。对于大肠杆菌菌株APEC_O2，已在多项研究中对质粒进行了测序和分析，因此，大肠杆菌APEC_O2可作为将来研究中的参考菌株。在这里，我们描述了大肠杆菌APEC_O2的染色体特征。大肠杆菌APEC_O2是ST135型序列，其染色体为4,908,820？bp（去除了质粒），包含4672个蛋白质编码基因，110个RNA基因和156个假基因，平均Gα+δC含量为50.69％。我们鉴定了8​​2条插入序列以及4672种蛋白质编码序列，12个预测的基因组岛，3个与噬菌体相关的序列以及染色体上的两个成簇的规则间隔的短回文重复序列区域，表明该菌株中可能发生水平基因转移。大肠杆菌APEC_O2的野生型菌株对多种抗菌药具有抗药性，但是，染色体上不存在（完整）抗生素抗性基因，但是已鉴定出许多与肠外疾病相关的基因。总之，此处提供的有关大肠杆菌APEC_O2的信息将有助于禽类致病性大肠杆菌菌株的进一步研究，尤其是有关大肠杆菌APEC_O2菌株的研究，并有助于对禽类致病性大肠杆菌的发病机理的一般理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号