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首页> 外文期刊>Romanian journal of physics >Biocompatibility Study of Magnetite Nanoparticle Synthesized Using a Green Method
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Biocompatibility Study of Magnetite Nanoparticle Synthesized Using a Green Method

机译：绿色法合成磁铁矿纳米颗粒的生物相容性研究

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The aim of our study was to characterize our new synthesized magnetite nanoparticles (NP), obtained by a less pollutant turmeric-assisted method and to evaluate their biocompatibility. Physical-chemical characterization was done using transmission electron microscopy (TEM) and selected area electron diffraction (SAED) in order to prove the high crystallinity of the nanoparticles and to identify the component phase. The in vitro biocompatibility studies were performed on normal fibroblasts (L929 cell line). The magnetite NP that we have synthesized does not induce cellular death or genotoxic effect. Analysis of metabolic function showed a transient decrease in metabolic capacity at 24 hours of incubation with the newly synthetized NP, but the cells regained quickly their normal function. The decrease in metabolic capacity was correlated with a temporary cell cycle block. These data suggest that the cells need a time interval to process the material. To further demonstrate that the NP are not toxic in a biological context we have performed a hemolysis assay showed no erythrocyte lysis. Our experiments conclude that the new synthesized NP obtained by a green method represent a biocompatible material and can be used in various biological applications.
机译：我们研究的目的是表征通过污染物较少的姜黄辅助方法获得的新型合成磁铁矿纳米颗粒（NP），并评估其生物相容性。使用透射电子显微镜（TEM）和选择区域电子衍射（SAED）进行了物理化学表征，以证明纳米粒子的高结晶度并鉴定组分相。在正常成纤维细胞（L929细胞系）上进行了体外生物相容性研究。我们合成的磁铁矿NP不会诱导细胞死亡或遗传毒性。代谢功能分析显示，与新合成的NP孵育24小时后，代谢能力会暂时降低，但细胞会迅速恢复其正常功能。代谢能力的下降与暂时的细胞周期阻滞有关。这些数据表明，单元需要一个时间间隔来处理材料。为了进一步证明NP在生物学背景下无毒，我们进行了溶血分析，未发现红细胞溶解。我们的实验得出的结论是，通过绿色方法获得的新合成NP代表了生物相容性材料，可用于各种生物学应用。

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