...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Stem cells international >Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration
【24h】

Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration

机译：椎间盘衍生的干/祖细胞作为椎间盘再生的有希望的细胞来源。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back pain. Despite remarkable improvements in both pharmacological and surgical management of IVD degeneration (IVDD), therapeutic effects are still unsatisfactory. It is because of the fact that these therapies are mainly focused on alleviating the symptoms rather than treating the underlying cause or restoring the structure and biomechanical function of the IVD. Accumulating evidence has revealed that the endogenous stem/progenitor cells exist in the IVD, and these cells might be a promising cell source in the regeneration of degenerated IVD. However, the biological characteristics and potential application of IVD-derived stem/progenitor cells (IVDSCs) have yet to be investigated in detail. In this review, the authors aim to perform a review to systematically discuss (1) the isolation, surface markers, classification, and biological characteristics of IVDSCs; (2) the aging- and degeneration-related changes of IVDSCs and the influences of IVD microenvironment on IVDSCs; and (3) the potential for IVDSCs to promote regeneration of degenerated IVD. The authors believe that this review exclusively address the current understanding of IVDSCs and provide a novel approach for the IVD regeneration.
机译：椎间盘（IVD）变性被认为是下腰痛的主要原因。尽管IVD变性（IVDD）的药理和外科治疗都有显着改善，但治疗效果仍不理想。因为这样的事实，这些疗法主要集中于减轻症状而不是治疗根本原因或恢复IVD的结构和生物力学功能。越来越多的证据表明，IVD中存在内源性干/祖细胞，这些细胞可能是退化IVD再生中有希望的细胞来源。但是，IVD来源的干/祖细胞（IVDSC）的生物学特性和潜在应用尚待详细研究。在这篇综述中，作者旨在进行综述以系统地讨论（1）IVDSC的分离，表面标记，分类和生物学特性; （2）IVDSC的衰老和变性相关变化以及IVD微环境对IVDSC的影响; （3）IVDSC促进变性IVD再生的潜力。作者认为，本综述专门针对当前对IVDSC的理解，并为IVD再生提供了一种新颖的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号