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The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke

机译：中风前血糖控制对急性缺血性中风严重程度和预后的作用

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Background/Aim. Relatively few studies have investigated the association of prestroke glycemic control and clinical outcome in acute ischemic stroke (IS) patients, regardless of presence of diabetes mellitus (DM). The aim of this study was to investigate the importance of prestroke glycemic control on survival, stroke severity, and functional outcome of patients with acute IS.Methods. We performed a retrospective survival analysis of 501 patients with IS admitted to Sahlgrenska University Hospital from February 15, 2005, through May 31, 2009. The outcomes of interest were acute and long-term survival; the stroke severity (NIHSS) and the functional outcome, mRS, at 12 months.Results. HbA1c was a good predictor of acute (HR 1.45; CI, 1.09 to 1.93,P=0.011) and long-term mortality (HR 1.29; CI 1.03 to 1.62;P=0.029). Furthermore, HbA1c >6% was significantly correlated with acute stroke severity (OR 1.29; CI 1.01 to 1.67;P=0.042) and predicted worse functional outcome at 12 months (OR 2.68; CI 1.14 to 6.03;P=0.024).Conclusions. Our study suggests that poor glycemic control (baseline HbA1c) prior to IS is an independent risk factor for poor survival and a marker for increased stroke severity and unfavorable long-term functional outcome.
机译：背景/目标。相对而言，很少有研究调查急性缺血性卒中（IS）患者的卒中前血糖控制与临床结局的相关性，而与糖尿病（DM）的存在无关。这项研究的目的是研究卒中前血糖控制对急性IS患者生存，卒中严重程度和功能结局的重要性。从2005年2月15日至2009年5月31日，我们对萨尔格伦斯卡大学医院收治的501例IS患者进行了回顾性生存分析。研究的目的是急性和长期生存。 12个月时的卒中严重程度（NIHSS）和功能结局mRS。 HbA1c是急性（HR 1.45; CI，1.09至1.93，P = 0.011）和长期死亡率（HR 1.29; CI 1.03至1.62; P = 0.029）的良好预测指标。此外，HbA1c> 6％与急性卒中严重程度显着相关（OR 1.29; CI 1.01至1.67; P = 0.042），并预测12个月时的功能转归较差（OR 2.68; CI 1.14至6.03; P = 0.024）。我们的研究表明，IS前的血糖控制不良（基线HbA1c）是生存不良的独立危险因素，并且是卒中严重程度增加和长期功能不良的标志。

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