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The sleep and circadian modulation of neural reward pathways: a protocol for a pair of systematic reviews

机译:神经奖励途径的睡眠和昼夜节律调节:一对系统评价的协议

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Animal research suggests that neural reward activation may be systematically modulated by sleep and circadian function. Whether humans also exhibit sleep and circadian modulation of neural reward pathways is unclear. This area is in need of further research, as it has implications for the involvement of sleep and circadian function in reward-related disorders. The aim of this paper is to describe the protocol for a pair of systematic literature reviews to synthesise existing literature related to (1) sleep and (2) circadian modulation of neural reward pathways in healthy human populations. A systematic review of relevant online databases (Scopus, PubMed, Web of Science, ProQuest, PsycINFO and EBSCOhost) will be conducted. Reference lists, relevant reviews and supplementary data will be searched for additional articles. Articles will be included if (a) they contain a sleep- or circadian-related predictor variable with a neural reward outcome variable, (b) use a functional magnetic resonance imaging protocol and (c) use human samples. Articles will be excluded if study participants had disorders known to affect the reward system. The articles will be screened by two independent authors. Two authors will complete the data extraction form, with two authors independently completing the quality assessment tool for the selected articles, with a consensus reached with a third author if needed. Narrative synthesis methods will be used to analyse the data. The findings from this pair of systematic literature reviews will assist in the identification of the pathways involved in the sleep and circadian function modulation of neural reward in healthy individuals, with implications for disorders characterised by dysregulation in sleep, circadian rhythms and reward function. PROSPERO CRD42017064994
机译:动物研究表明,神经奖励激活可能通过睡眠和昼夜节律功能进行系统调节。人类是否还表现出睡眠和神经奖励途径的昼夜节律调节尚不清楚。这个领域需要进一步的研究,因为它对睡眠和昼夜节律功能参与奖励相关疾病具有影响。本文的目的是描述用于一对系统文献综述的方案,以合成与健康人群中的(1)睡眠和(2)昼夜节律调节神经奖励途径有关的现有文献。将对相关的在线数据库(Scopus,PubMed,Web of Science,ProQuest,PsycINFO和EBSCOhost)进行系统的审查。将在参考列表,相关评论和补充数据中搜索其他文章。如果文章(a)包含与睡眠或昼夜节律有关的预测变量以及神经奖励结果变量,(b)使用功能性磁共振成像协议,并且(c)使用人类样本,则将包括这些文章。如果研究参与者患有已知会影响奖励系统的疾病,则将其排除在外。文章将由两名独立作者进行筛选。两名作者将完成数据提取表格,两名作者将独立完成所选文章的质量评估工具,并在需要时与第三名作者达成共识。叙事综合方法将用于分析数据。这对系统的文献综述的结果将有助于确定健康个体的睡眠和神经奖励的昼夜节律功能调节所涉及的途径,并涉及以睡眠失调,昼夜节律和奖赏功能为特征的疾病。宝珀CRD42017064994

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