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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People
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Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People

机译：慢性广泛性疼痛和纤维肌痛综合征：年轻人生命过程中的危险标志

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摘要

Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and progression of CWP and FMS include genetic factors, premature birth, female sex, early childhood adversity, cognitive and psychosocial influences, impaired sleep, primary pain disorders, multiregional pain, physical trauma, infectious illness, obesity and inactivity, hypermobility of joints, iron deficiency, and small-fiber polyneuropathy. The case history illustrates the potential etiological influence of multiple risk markers offset by personal resilience.
机译：尽管在流行病学中已经将危险标记物作为潜在病因的生命过程概念已经确立，但在慢性广泛性疼痛（CWP）和纤维肌痛综合征（FMS）的背景下，它尚未在学术出版物或临床实践中得到体现。风险标志物的研究是评估患者和进行研究的必要考虑因素，因为对于CWP或FMS没有单一的原因，病理特征，实验室检查或生物标志物。通过广泛的文献综述确定的早期生命危险标志物，有最佳证据表明对CWP和FMS的发生和发展有潜在的因果影响，包括遗传因素，早产，女性，早期逆境，认知和社会心理影响，睡眠障碍，原发性疼痛疾病，多区域疼痛，身体创伤，传染病，肥胖和不活动，关节活动过度，铁缺乏症和小纤维多神经病。病历说明了个人抵御能力抵消了多种风险标志物的潜在病因。

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