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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Reward Processing under Chronic Pain from the Perspective of “Liking” and “Wanting”: A Narrative Review
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Reward Processing under Chronic Pain from the Perspective of “Liking” and “Wanting”: A Narrative Review

机译：从“喜欢”和“渴望”的角度看慢性疼痛下的奖励处理：叙事回顾

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摘要

The therapeutic goals of patients with chronic pain are not only to relieve pain but also to improve the quality of life. Chronic pain negatively affects various aspects of daily life, such as by decreasing the motivation to work and reward sensitivity, which may lead to difficulties in daily life or even unemployment. Human and animal studies have shown that chronic pain damages reward processing; the exploration of associated internal mechanisms may aid the development of treatments to repair this damage. Incentive salience theory, used widely to describe reward processing, divides this processing into “liking” (reward-induced hedonic sensory impact) and “wanting” (reward-induced motivation) components. It has been employed to explain pathological changes in reward processing induced by psychiatric disorders. In this review, we summarize the findings of studies of reward processing under chronic pain and examine the effects of chronic pain on “liking” and “wanting.” Evidence indicates that chronic pain compromises the “wanting” component of reward processing; we also discuss the neural mechanisms that may mediate this effect. We hope that this review aids the development of therapies to improve the quality of life of patients with chronic pain.
机译：患有慢性疼痛的患者的治疗目标不仅是缓解疼痛，还在于改善生活质量。慢性疼痛会对日常生活的各个方面产生负面影响，例如降低工作动机和奖励敏感性，这可能会导致日常生活困难甚至失业。人类和动物研究表明，慢性疼痛会损害奖励过程。探索相关的内部机制可能有助于修复这种损害的治疗方法。奖励显着性理论被广泛用于描述奖励过程，将该过程分为“喜欢”（奖励引起的享乐感官冲击）和“想要”（奖励引起的动机）两部分。它已被用来解释由精神疾病引起的奖赏过程中的病理变化。在这篇综述中，我们总结了慢性疼痛下奖励加工的研究结果，并研究了慢性疼痛对“喜欢”和“想要”的影响。有证据表明，慢性疼痛损害了奖励过程的“希望”组成部分。我们还将讨论可能介导这种作用的神经机制。我们希望这篇综述有助于开发疗法以改善慢性疼痛患者的生活质量。

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