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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Risk Factors and Prevention Strategies for Postoperative Opioid Abuse
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Risk Factors and Prevention Strategies for Postoperative Opioid Abuse

机译：术后阿片类药物滥用的危险因素及预防策略

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摘要

Worldwide, 80% of patients who undergo surgery receive opioid analgesics as the fundamental agent for pain relief. However, the irrational use of opioids leads to excessive drug dependence and drug abuse, resulting in an increased mortality rate and huge economic loss. The crisis of opioid overuse remains a great challenge. In this review, we summarize several key factors in opioid abuse, including race, region, income, genetic factors, age and gender, smoking and alcohol abuse, history of chronic pain and analgesic drug abuse, surgery, neuropsychiatric illness, depression and antidepressant use, human factors, national policies, hospital regulations, and health insurance under treatment of pain. Furthermore, we present several prevention strategies, such as perioperative measures, opioid substitutes, treatment of the primary illness, emotional regulation, use of opioid antagonists, efforts of the state, hospitals, doctors and pharmacy benefit managers, gene therapy, and vaccines. Greater understanding and better assessment are required of the risks associated with opioid abuse to ensure the safety and analgesic effects of pain treatment after surgery.
机译：在全球范围内，接受手术的患者中有80％接受阿片类镇痛药作为缓解疼痛的基本药物。但是，不合理使用阿片类药物会导致过度的药物依赖和药物滥用，导致死亡率增加和巨大的经济损失。阿片类药物滥用的危机仍然是一个巨大的挑战。在这篇综述中，我们总结了阿片类药物滥用的几个关键因素，包括种族，地区，收入，遗传因素，年龄和性别，吸烟和酗酒，慢性疼痛和止痛药滥用的历史，手术，神经精神病，抑郁症和抗抑郁药的使用。 ，人为因素，国家政策，医院法规以及治疗疼痛的健康保险。此外，我们提出了几种预防策略，例如围手术期措施，阿片类药物替代品，原发疾病的治疗，情绪调节，阿片类药物拮抗剂的使用，国家，医院，医生和药房福利管理者的努力，基因疗法和疫苗。需要对与阿片类药物滥用相关的风险有更多的了解和更好的评估，以确保术后疼痛治疗的安全性和镇痛作用。

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