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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Effects of MRgFUS Treatment on Musculoskeletal Pain: Comparison between Bone Metastasis and Chronic Knee/Lumbar Osteoarthritis
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Effects of MRgFUS Treatment on Musculoskeletal Pain: Comparison between Bone Metastasis and Chronic Knee/Lumbar Osteoarthritis

机译：MRgFUS治疗对肌肉骨骼疼痛的影响：骨转移与慢性膝/腰椎骨关节炎的比较

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摘要

Local bone denervation by magnetic resonance-guided focused ultrasound (MRgFUS) is a promising tool for alleviation of pain in patients with painful bone metastasis (BM). Considering the underlying mechanism of pain alleviation, MRgFUS might be effective for various bone and joint diseases associated with local tenderness. This study was conducted to clarify the therapeutic effect of focused ultrasound in patients with various painful bone and joint diseases that are associated with local tenderness. Ten patients with BM, 11 patients with lumbar facet joint osteoarthritis (L-OA), and 19 patients with knee osteoarthritis (K-OA) were included. MRgFUS treatment was applied to the bone surface with real-time temperature monitoring at the target sites. Pain intensity was assessed using a 100?mm numerical rating scale (NRS) at various time points. Pressure pain threshold (PPT) was evaluated on the sonication area and control sites. Compared to baseline, the pain NRS scores significantly decreased in all groups 1?month after treatment, and PPT at the treated sites significantly increased in all groups 3?months after treatment. The percentage of patients who showed a ≥ 50% decrease in pain NRS scores at 1?month after treatment was 80% in BM, 64% in L-OA, and 78% in K-OA groups. PPTs were significantly higher after treatment at all evaluation time points. This study indicated that MRgFUS is effective in reducing pressure pain at the site of most severe tenderness in patients with painful bone and joint diseases. Treatment response was comparable between patients with BM, L-OA, and K-OA.
机译：通过磁共振引导聚焦超声（MRgFUS）进行局部骨骼去神经是减轻疼痛性骨转移（BM）患者疼痛的有前途的工具。考虑到缓解疼痛的潜在机制，MRgFUS可能对与局部压痛有关的各种骨骼和关节疾病有效。进行这项研究是为了阐明聚焦超声在患有各种与局部压痛有关的疼痛性骨和关节疾病的患者中的治疗效果。包括10例BM患者，11例腰椎小关节骨关节炎（L-OA）和19例膝关节骨关节炎（K-OA）。通过对目标部位进行实时温度监测，将MRgFUS治疗应用于骨骼表面。在各个时间点使用100？mm的数字评分量表（NRS）评估疼痛强度。在超声区域和对照部位评估压力痛阈值（PPT）。与基线相比，治疗后1个月所有组的疼痛NRS评分均显着降低，治疗后3个月所有组的治疗部位PPT均显着升高。在治疗后1个月，疼痛NRS评分降低≥50％的患者中，BM组为80％，L-OA组为64％，K-OA组为78％。治疗后所有评估时间点的PPT均显着较高。这项研究表明，MRgFUS可有效减轻骨和关节疾病患者的最严重压痛部位的压力疼痛。 BM，L-OA和K-OA患者的治疗反应相当。

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