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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Magnesium Sulfate as Adjuvant in Prehospital Femoral Nerve Block for a Patient with Diaphysial Femoral Fracture: A Randomized Controlled Trial
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Magnesium Sulfate as Adjuvant in Prehospital Femoral Nerve Block for a Patient with Diaphysial Femoral Fracture: A Randomized Controlled Trial

机译：硫酸镁作为骨干股骨骨折患者院前股神经阻滞的佐剂：一项随机对照试验

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Introduction. Prehospital management of traumatic pain is commonly based on morphine while locoregional analgesia techniques, especially the femoral nerve block (FNB), can be safely and efficiently used. Adjuvants uses can reduce local anesthetic doses and decrease their related risk. The aim of the study was to assess the analgesic effect of magnesium sulfate when used as an adjuvant in prehospital FNB. Methods. This is a randomized double-blinded trial conducted in a prehospital medical department of an academic hospital. Patients with isolated diaphysial femoral fracture and eligible to participate were randomized into 2 groups. Group C had a FNB with 15?ml of lidocaine with epinephrine (300?mg) and 3?ml of normal saline solution. Group I had a FNB with 15?ml of lidocaine with epinephrine (300?mg) and 3?ml of MgS 15% (450?mg). The FNB was performed according to the WINNIE technique. Primary endpoints were morphine consumption and pain intensity during the first 6 hours. Secondary endpoints were the duration of the sensory block, time to the first analgesic request, and side effects occurrence. Results. Twenty-four patients were enrolled in each group. Both groups were comparable according to demographic characteristics, initial pain scores, and vital constants. In group I, morphine requirements were significantly lower (2 ± 2?mg versus 5 ± 3?mg, ), analgesic onset was significantly faster, and the average time to the first analgesic request was longer (276 ± 139?min versus 160 ± 79?min, ). The average duration of sensory block was longer in group I (226 ± 64?min versus 116 ± 70?min ). No side effects were recorded. Conclusion. Magnesium sulfate should be considered as an efficient and safe adjuvant to lidocaine in prehospital FNB. This trial is registered with (NCT03597945).
机译：介绍。院前对创伤性疼痛的治疗通常基于吗啡，而局部镇痛技术，尤其是股神经阻滞（FNB），可以安全有效地使用。佐剂的使用可以减少局部麻醉剂量并降低其相关风险。该研究的目的是评估硫酸镁作为院前FNB的佐剂的镇痛作用。方法。这是在学术医院院前医疗部门进行的一项随机双盲试验。骨干分离型股骨骨折并符合条件的患者被随机分为两组。 C组的FNB含15毫升利多卡因，肾上腺素（300毫克）和3毫升生理盐水。第一组患者有一个FNB，其中含15？ml利多卡因和肾上腺素（300？mg），以及3？ml的MgS 15％（450？mg）。根据WINNIE技术执行FNB。主要终点为头6小时内的吗啡消耗量和疼痛强度。次要终点是感觉阻滞的持续时间，第一次镇痛的时间和副作用的发生。结果。每组二十四名患者入组。根据人口统计学特征，初始疼痛评分和生命常数，两组均具有可比性。在第一组中，吗啡需求量显着降低（2±2？mg比5±3？mg，），镇痛作用明显更快，首次镇痛的平均时间更长（276±139？min与160± 79分钟，）。 I组的平均感觉阻滞持续时间更长（226±64？min与116±70？min）。没有副作用记录。结论。硫酸镁应被认为是院前FNB中利多卡因的有效和安全佐剂。该试用版已向（NCT03597945）注册。

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