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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Elevated Levels of Eotaxin-2 in Serum of Fibromyalgia Patients
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Elevated Levels of Eotaxin-2 in Serum of Fibromyalgia Patients

机译：纤维肌痛患者血清中Eotaxin-2水平升高

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FMS patients demonstrate an altered profile of chemokines relative to healthy controls (HC). Eotaxin-2 is a potent chemoattractant distributed in a variety of tissues. The aim of the study was to compare serum levels of eotaxin-2 between FMS patients and HC and to examine a potential correlation between eotaxin-2 levels and clinical parameters of FMS. Methods. 50 patients with FMS and 15 HC were recruited. Data on the severity of FMS symptoms and depression were collected. Serum levels of eotaxin-2 (ELISA) were determined in all participants. High-sensitive CRP (hs-CRP) was measured in the FMS group. Results. The FMS cohort included predominantly females (84%), mean age of 49, and mean disease duration of 6 years. FMS patients exhibited significantly higher eotaxin-2 levels (pg/ml) versus HC: 833 (±384) versus 622 (±149), . Mean hs-CRP level among FMS patients was 4.8?±?6?mg/l, a value not indicative of acute inflammation. No correlation was found between eotaxin-2 and hs-CRP levels. No correlation was found between eotaxin-2 and severity measures of FMS or depression. Conclusion. Eotaxin-2 does not appear to be a candidate for a disease activity biomarker in FMS. Further research is warranted into the role of this chemokine in the pathophysiology of the FMS.
机译：FMS患者表现出趋化因子相对于健康对照（HC）的变化。 Eotaxin-2是一种有效的化学引诱剂，分布于多种组织中。该研究的目的是比较FMS患者和HC之间的血清eotaxin-2水平，并检查eotaxin-2水平与FMS临床参数之间的潜在相关性。方法。招募了50名FMS和15 HC患者。收集有关FMS症状和抑郁严重程度的数据。测定所有参与者的血清eotaxin-2（ELISA）水平。在FMS组中测量高敏CRP（hs-CRP）。结果。 FMS队列主要包括女性（84％），平均年龄49岁，平均病程6年。与HC相比，FMS患者的eotaxin-2水平（pg / ml）明显更高：833（±384）对622（±149）。 FMS患者的hs-CRP平均水平为4.8？±？6？mg / l，该值并不表示急性炎症。在eotaxin-2和hs-CRP水平之间未发现相关性。 Eotaxin-2与FMS或抑郁的严重程度之间没有相关性。结论。 Eotaxin-2在FMS中似乎不是疾病活动生物标志物的候选者。需要进一步研究这种趋化因子在FMS病理生理中的作用。

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